EP 0000036 A1 19781220 - Fluorinated alkylamines and process for preparing same.

Title (en)

Fluorinated alkylamines and process for preparing same.

Title (de)

Fluorierte Alkylamine und Verfahren zu ihrer Herstellung.

Title (fr)

Alkylamines fluorées et procédé pour leur préparation.

Publication

EP 0000036 A1 19781220 (EN)

Application

EP 78100059 A 19780601

Priority

US 80235077 A 19770601

Abstract (en)

1-Fluoromethyl-substituted alkyl-amines of formula: R - CH(CH2F) - NH2 are disclosed. R can be 3,4-diR10- benzyle, (R1 is hydrogen or C2-C6 alkanoyl), hydroxybenzyl, benzyl, 4-methylene-imidazole, 3-methylene- 5-hydroxy-indole, 3-methylene- indole, 2-carboxyethyl, 3-carboxy-3- aminopropyl, and 4 carboxy-4 amino-butyl. These compounds can be prepared by fluorinating the corresponding 1-hydroxymethyl- substituted alkylamines, or the corresponding 1-methyl- alkylamines. They have decarboxylase inhibiting activity.

IPC 1-7

C07C 87/28; C07C 91/30; C07C 91/32; C07C 93/26; C07C 101/10; C07C 101/24; C07D 209/16; C07D 233/64

IPC 8 full level

A61K 31/13 (2006.01); A61K 31/19 (2006.01); A61K 31/195 (2006.01); A61K 31/215 (2006.01); A61K 31/395 (2006.01); A61P 9/02 (2006.01); A61P 9/12 (2006.01); A61P 43/00 (2006.01); C07C 67/00 (2006.01); C07C 213/00 (2006.01); C07C 215/52 (2006.01); C07C 219/28 (2006.01); A61K 31/135 (2006.01); C07C 227/00 (2006.01); C07C 227/16 (2006.01); C07C 229/20 (2006.01); C07C 229/26 (2006.01); C07D 209/12 (2006.01); C07D 209/14 (2006.01); C07D 209/16 (2006.01); C07D 233/54 (2006.01); C07D 233/64 (2006.01)

CPC (source: EP)

A61P 9/02 (2018.01); A61P 9/12 (2018.01); A61P 43/00 (2018.01); C07D 209/16 (2013.01); C07D 233/64 (2013.01)

Citation (applicant)

D. M. AVIADO: "Sympathomimetic Drugs", 1970, CHARLES C. THOMAS
JOURNAL OF ORGANIC CHEMISTRY, vol. 40, 1975, pages 3809 - 10
J. AM. CHEM. SOC., vol. 98, 1976, pages 5591
J. AM. CHEM. SOC., vol. 92, 1970, pages 7494
J. OF AM. CHEM. SOC., vol. 98, 1976, pages 5591 - 93
J. OF AM. CHEM. SOC., vol. 92, 1970, pages 7494

Citation (search report)

[A] GB 976353 A 19641125 - SCIENCE UNION & CIE SOC FR DE
[A] GB 1218135 A 19710106 - ABBOTT LAB [US]
[A] US 3839170 A 19741001 - KOLLONITSCH J

Designated contracting state (EPC)

BE CH DE FR GB LU NL SE

DOCDB simple family (publication)

EP 0000036 A1 19781220; EP 0000036 B1 19811014; DE 2861148 D1 19811224; DK 240578 A 19781202; IE 46910 B1 19831102; IE 781076 L 19781201; IT 1104712 B 19851028; IT 7849634 A0 19780531; JP S5416422 A 19790207; JP S6123177 B2 19860604

DOCDB simple family (application)

EP 78100059 A 19780601; DE 2861148 T 19780601; DK 240578 A 19780531; IE 107678 A 19780530; IT 4963478 A 19780531; JP 6501478 A 19780601