EP 0000078 B1 19800723 - PREPARATION OF SALTS OF HYDROXYPHOSPHINYLUREIDOBENZYLPENICILLINS.
Title (en)
PREPARATION OF SALTS OF HYDROXYPHOSPHINYLUREIDOBENZYLPENICILLINS.
Publication
Application
Priority
GB 2322777 A 19770601
Abstract (en)
[origin: EP0000078A1] The invention relates to a process in which a 3,5:4,6-protected derivative of L- or D-glulonic acid is prepared by contacting L- or D-gulono-1,4-lactone with an aldehyde dialkyl acetal, or with an aldehyde and an alcohol, in the presence of an acid having a pKa of less than 3. This protected derivative may be oxidised and hydrolysed to 2-keto-L- or D-gulonic acid or ester thereof, which in turn may be hydrolysed to L- or D-ascorbic acid. L-ascorbic acid is of course Vitamin C. The invention also relates to the novel intermediates produced by the above processes.
IPC 1-7
IPC 8 full level
C07D 499/00 (2006.01); C07D 499/04 (2006.01); C07D 499/64 (2006.01); C07D 499/68 (2006.01); C07F 9/6561 (2006.01)
IPC 8 main group level
C07F (2006.01)
CPC (source: EP US)
C07D 499/00 (2013.01 - EP US); C07F 9/65611 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0000078 A1 19781220; EP 0000078 B1 19800723; DE 2860040 D1 19801113; DK 239278 A 19781202; DK 468680 A 19801104; FI 781686 A 19781202; IT 7868198 A0 19780525; JP S543093 A 19790111; US 4177189 A 19791204
DOCDB simple family (application)
EP 78200017 A 19780601; DE 2860040 T 19780601; DK 239278 A 19780530; DK 468680 A 19801104; FI 781686 A 19780526; IT 6819878 A 19780525; JP 6487078 A 19780530; US 90822178 A 19780522