EP 0000150 B1 19810520 - DIHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
Title (en)
DIHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
Publication
Application
Priority
- CH 286578 A 19780316
- CH 752077 A 19770620
Abstract (en)
[origin: EP0000150A1] Compounds of formula I, <CHEM> wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl or alkinyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 8 carbon atoms, phenylalkyl of 7 to 9 carbon atoms or phenylalkenyl of 9 to 12 carbon atoms, the phenyl ring being unsubstituted or monodi-, or trisubstituted independently by halogen, hydroxy or alkyl or alkoxy of 1 to 4 carbon atoms, R2 and R5, independently, are hydrogen or alkyl of 1 to 6 carbon atoms, R3 and R4, independently, are alkyl of 1 to 6 carbon atoms, alkenyl or alkinyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 8 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxyalkoxy of 2 to 6 carbon atoms, alkoxyalkoxy of 3 to 6 carbon atoms, hydroxyalkoxyalkoxy of 4 to 8 carbon atoms, alkenyloxy or alkinyloxy of 3 to 6 carbon atoms, cycloalkyloxy of 3 to 7 carbon atoms or cycloalkylalkoxy of 4 to 8 carbon atoms, R6 is hydrogen, halogen, alkyl or alkoxy or alkylthio or alkylsulfonyl, each of 1 to 4 carbon atoms, trifluoromethyl, nitro or hydroxy, and is oxygen or sulphur are useful for treating coronary insufficiency and hypertension.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61K 31/44 (2006.01); A61K 31/445 (2006.01); A61K 31/455 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01)
CPC (source: EP)
A61K 31/44 (2013.01); A61P 9/08 (2018.01); A61P 9/10 (2018.01); A61P 9/12 (2018.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01)
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0000150 A1 19790110; EP 0000150 B1 19810520; AT 376220 B 19841025; AT A443178 A 19840315; AU 3725278 A 19800103; AU 524000 B2 19820826; CA 1105463 A 19810721; CY 1239 A 19840629; DE 2860708 D1 19810827; DK 149855 B 19861013; DK 149855 C 19870421; DK 262578 A 19781221; ES 470917 A1 19791001; FI 64938 B 19831031; FI 64938 C 19840210; FI 781867 A 19781221; HK 65184 A 19840831; IE 47212 B1 19840125; IE 781231 L 19781220; IL 54948 A0 19780831; IL 54948 A 19820131; IT 1105364 B 19851028; IT 7849939 A0 19780619; JP S54103876 A 19790815; JP S6360755 B2 19881125; LU 88342 I2 19940504; MY 8500041 A 19851231; NL 930126 I1 19931101; NL 930126 I2 19950216; NZ 187617 A 19801219; PT 68191 A 19780701; SG 20584 G 19850308
DOCDB simple family (application)
EP 78100165 A 19780615; AT 443178 A 19780619; AU 3725278 A 19780619; CA 305727 A 19780619; CY 123978 A 19780615; DE 2860708 T 19780615; DK 262578 A 19780612; ES 470917 A 19780619; FI 781867 A 19780612; HK 65184 A 19840823; IE 123178 A 19780619; IL 5494878 A 19780619; IT 4993978 A 19780619; JP 7332778 A 19780619; LU 88342 C 19930630; MY 8500041 A 19851230; NL 930126 C 19930701; NZ 18761778 A 19780619; PT 6819178 A 19780619; SG 20584 A 19840305