EP 0000243 B1 19810107 - PROCESS FOR PREPARING 3,5:4,6- PROTECTED DERIVATIVES OF L- OR D- GULONIC ACID, THEIR USE IN PREPARING 2- KETO-L- OR D- GULONIC ACID OR THEIR ESTERS OR L- OR D- ASCORBIC ACID, AND CERTAIN NOVEL 2-NITRATO-GULONATE INTERMEDIATES
Title (en)
PROCESS FOR PREPARING 3,5:4,6- PROTECTED DERIVATIVES OF L- OR D- GULONIC ACID, THEIR USE IN PREPARING 2- KETO-L- OR D- GULONIC ACID OR THEIR ESTERS OR L- OR D- ASCORBIC ACID, AND CERTAIN NOVEL 2-NITRATO-GULONATE INTERMEDIATES
Publication
Application
Priority
US 80588077 A 19770613
Abstract (en)
[origin: EP0000243A1] The invention relates to a process in which a 3,5:4,6-protected derivative of L- or D-glulonic acid is prepared by contecting L- or D-gulono-1,4-lactone with an aldehyde dialkyl acetal, or with an aldehyde and an alcohol, in the presence of an acid having a pKa of less than 3. This protected derivative may be oxidised and hydrolysed to 2-keto-L- or D-gulonic acid or ester thereof, which in turn may be hydrolysed to L- or D-ascorbic acid. L-ascorbic acid is of course Vitamin C. The invention also relates to the novel intermediates produced by the above processes.
IPC 1-7
IPC 8 full level
C07D 307/62 (2006.01); C07D 493/04 (2006.01); C07H 7/02 (2006.01); C07H 7/027 (2006.01); C07H 9/04 (2006.01)
CPC (source: EP US)
C07D 307/62 (2013.01 - EP US); C07D 493/04 (2013.01 - EP US); C07H 7/027 (2013.01 - EP US); C07H 9/04 (2013.01 - EP US)
Designated contracting state (EPC)
BE CH DE FR GB LU NL
DOCDB simple family (publication)
EP 0000243 A1 19790110; EP 0000243 B1 19810107; CA 1096397 A 19810224; DE 2860399 D1 19810226; DK 262178 A 19781214; IE 47197 B1 19840111; IE 781171 L 19781213; IT 1096711 B 19850826; IT 7824473 A0 19780612; JP S545917 A 19790117; JP S563357 B2 19810124; US 4232168 A 19801104
DOCDB simple family (application)
EP 78300017 A 19780605; CA 305179 A 19780609; DE 2860399 T 19780605; DK 262178 A 19780612; IE 117178 A 19780609; IT 2447378 A 19780612; JP 7070578 A 19780612; US 80588077 A 19770613