EP 0000258 B1 19810311 - POLYCYCLIC ETHER ANTIBIOTICS, PROCESS FOR PRODUCING THEM AND ANIMAL FEED COMPOSITIONS CONTAINING THEM
Title (en)
POLYCYCLIC ETHER ANTIBIOTICS, PROCESS FOR PRODUCING THEM AND ANIMAL FEED COMPOSITIONS CONTAINING THEM
Publication
Application
Priority
US 80962077 A 19770624
Abstract (en)
[origin: EP0000258A1] Antibiotics 47,433 and 47,434 are produced by culture of Actinomycete micro-organism ATCC 31286, and are useful for controlling coccidiosis in poultry by administration in the diet, and for improving feed utilisation in ruminants and monogastric animals. <??>Antibiotic 47,433 as crystalline free acid is soluble in methanol, acetone, chloroform, methylisobutyl ketone, ethyl acetate and insoluble in water; m.p. 89-99 DEG C; ( alpha )D = +16 DEG (C = 1.0, MeOH); average composition by weight: 64.92% carbon, 9.73% hydrogen and 25.35% oxygen (by difference); infrared absorption (KBr pellets, in microns):2.87, 3.42, 5.77, 6.85, 7.30, 8.05, 8.60, 9.20, 10.15, 10.53 and 11.45; following crystalline salts are described: -Na(m.p. 226-32 DEG ; ( alpha )D = -0.2 DEG (C = 1.0, MeOH), -K (m.p. 202.-5 DEG ; ( alpha )D = -3.2 (C = 1.0, MeOH), -Ag (m.p. 180-2 DEG ; ( alpha )D = +3.6 DEG (C = 1.0, MeOH). Antibiotic 47.434 as crystalline sodium salt is soluble in chloroform, ethyl acetate, methylisobutyl ketone and insoluble in water; m.p. 230-238 DEG C, ( alpha )D = -1.3 DEG (C = 1.0, MeOH); infra-red absorption (KBr pellets, in microns): 3.40, 6.40, 6.85, 7.14, 7.27, 7.75, 8.05, 8.40, 8.62, 9.10, 9.40, 10.07, 10.50, 11.49, 12.65 and 13.25.
IPC 1-7
IPC 8 full level
A23K 20/195 (2016.01); A61K 31/325 (2006.01); A61K 31/35 (2006.01); A61K 35/74 (2006.01); C07D 493/10 (2006.01); A61P 31/00 (2006.01); A61P 33/02 (2006.01); C07G 11/00 (2006.01); C12P 1/06 (2006.01); C12P 17/18 (2006.01); C12R 1/03 (2006.01)
CPC (source: EP US)
A61P 31/00 (2018.01 - EP); A61P 33/02 (2018.01 - EP); C07G 11/00 (2013.01 - EP US); Y10S 435/826 (2013.01 - EP US)
Designated contracting state (EPC)
BE DE FR GB LU NL
DOCDB simple family (publication)
EP 0000258 A1 19790110; EP 0000258 B1 19810311; CA 1131145 A 19820907; DE 2860512 D1 19810409; DK 283578 A 19781225; IE 47005 B1 19831130; IE 781254 L 19781224; IT 1097275 B 19850831; IT 7824912 A0 19780623; JP S5412302 A 19790130; JP S57154187 A 19820922; JP S57154188 A 19820922; JP S5735915 B2 19820731; US 4148882 A 19790410
DOCDB simple family (application)
EP 78300057 A 19780620; CA 306039 A 19780622; DE 2860512 T 19780620; DK 283578 A 19780623; IE 125478 A 19780623; IT 2491278 A 19780623; JP 2672282 A 19820220; JP 2672382 A 19820220; JP 7634878 A 19780623; US 80962077 A 19770624