EP 0000338 A2 19790124 - Isoxazolo(5,4-c)pyridine derivatives, their preparation and pharmaceutical compositions containing them.
Title (en)
Isoxazolo(5,4-c)pyridine derivatives, their preparation and pharmaceutical compositions containing them.
Title (de)
Isoxazolo(5,4-c)pyridinderivate, ihre Herstellung und pharmazeutische Präparate welche diese enthalten.
Title (fr)
Dérivés de la isoxazolo(5,4-c)pyridine, leur préparation et composition pharmaceutique les contenant.
Publication
Application
Priority
GB 2574077 A 19770620
Abstract (en)
Isoxazolo-(5,4-C)-pyridine derivatives of the formula <CHEM> in which R sec is hydrogen, acetyl or a group of the formula R5OCO- in which R5 is C1-8-alkyl, phenyl, substituted phenyl; phenylalkyl or substituted phenylalkyl and salts thereof, and intermediates IV, VIII min , IX min and V. Compounds (I) may be prepared according to the following reaction scheme: <CHEM> in which Z is hydrogen or a protecting group, T is a group convertible by hydrolysis into an oxo group, Q is a leaving group and W is hydrogen or a group removable to yield the free hydroxy group. Compounds (I) exhibit a gamma -aminobutyric acid related activity and are useful as active ingredients in pharmaceutical compositions which may, optionally, further contain a minor tranquilizer or a neuroleptic.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61P 9/10 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); C07D 211/62 (2006.01); C07D 211/78 (2006.01); C07D 491/10 (2006.01); C07D 498/04 (2006.01)
CPC (source: EP US)
A61P 9/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/08 (2018.01 - EP); C07D 211/62 (2013.01 - EP US); C07D 211/78 (2013.01 - EP US); C07D 491/10 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0028017 A1 19810506; AT 368505 B 19821025; AT A448678 A 19820215; AU 3724478 A 19800103; AU 3729878 A 19800103; AU 521040 B2 19820311; CA 1107736 A 19810825; DK 270278 A 19781221; DK 270378 A 19781221; EP 0000167 A1 19790110; EP 0000338 A2 19790124; EP 0000338 A3 19790627; EP 0000338 B1 19811125; EP 0027279 A1 19810422; ES 470912 A1 19790201; ES 470913 A1 19790201; FI 64376 B 19830729; FI 64376 C 19831110; FI 781954 A 19781221; FI 781955 A 19781221; IE 47200 B1 19840111; IE 781234 L 19781220; IT 1159739 B 19870304; IT 7868449 A0 19780620; IT 7868450 A0 19780620; JP S5436275 A 19790316; JP S5436290 A 19790316; NO 152049 B 19850415; NO 152049 C 19850724; NO 782127 L 19781221; NO 782128 L 19781221; NO 792839 L 19781221; NZ 187615 A 19811215; US 4278676 A 19810714; US 4301287 A 19811117; ZA 783492 B 19790627; ZA 783493 B 19790627
DOCDB simple family (application)
EP 80106498 A 19780619; AT 448678 A 19780620; AU 3724478 A 19780619; AU 3729878 A 19780620; CA 305798 A 19780620; DK 270278 A 19780615; DK 270378 A 19780615; EP 78100190 A 19780619; EP 78100191 A 19780619; EP 80106497 A 19780619; ES 470912 A 19780619; ES 470913 A 19780619; FI 781954 A 19780619; FI 781955 A 19780619; IE 123478 A 19780619; IT 6844978 A 19780620; IT 6845078 A 19780620; JP 7479978 A 19780620; JP 7480078 A 19780620; NO 782127 A 19780619; NO 782128 A 19780619; NO 792839 A 19790903; NZ 18761578 A 19780619; US 10408079 A 19791217; US 91711878 A 19780619; ZA 783492 A 19780619; ZA 783493 A 19780619