EP 0000338 B1 19811125 - ISOXAZOLO(5,4-C)PYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Title (en)
ISOXAZOLO(5,4-C)PYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Publication
Application
Priority
GB 2574077 A 19770620
Abstract (en)
[origin: EP0028017A1] The compounds <CHEM> in which Alk is a lower alkyl group and Z is hydrogen or an amino-protecting group: <CHEM> wherein Z is hydrogen or an amino-protecting group, T is a group convertible, by hydrolysis, into an oxy group, and Q is a leaving group which, on reaction with hydroxylamine, forms a hydroxamic acid group; <CHEM> wherein Z and T are as defined above, are novel intermediates or preparing compound I. <CHEM> in which R sec is hydrogen, acetyl or a group of the general formula VII R5 - O - @ - vii in which R5 is C1-8 alkyl; phenyl; phenyl substituted in the 4-position with halogen, C1-4 alkoxy, or C1-4 alkyl; or phenylalkyl in which the phenyl group may be substituted in the 4-position with halogen, lower alkoxy, or lower alkyl; and salts thereof. The compound I, in which R sec is hydrogen, possesses GABA-related activity.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61P 9/10 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); C07D 211/62 (2006.01); C07D 211/78 (2006.01); C07D 491/10 (2006.01); C07D 498/04 (2006.01)
CPC (source: EP US)
A61P 9/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/08 (2018.01 - EP); C07D 211/62 (2013.01 - EP US); C07D 211/78 (2013.01 - EP US); C07D 491/10 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0028017 A1 19810506; AT 368505 B 19821025; AT A448678 A 19820215; AU 3724478 A 19800103; AU 3729878 A 19800103; AU 521040 B2 19820311; CA 1107736 A 19810825; DK 270278 A 19781221; DK 270378 A 19781221; EP 0000167 A1 19790110; EP 0000338 A2 19790124; EP 0000338 A3 19790627; EP 0000338 B1 19811125; EP 0027279 A1 19810422; ES 470912 A1 19790201; ES 470913 A1 19790201; FI 64376 B 19830729; FI 64376 C 19831110; FI 781954 A 19781221; FI 781955 A 19781221; IE 47200 B1 19840111; IE 781234 L 19781220; IT 1159739 B 19870304; IT 7868449 A0 19780620; IT 7868450 A0 19780620; JP S5436275 A 19790316; JP S5436290 A 19790316; NO 152049 B 19850415; NO 152049 C 19850724; NO 782127 L 19781221; NO 782128 L 19781221; NO 792839 L 19781221; NZ 187615 A 19811215; US 4278676 A 19810714; US 4301287 A 19811117; ZA 783492 B 19790627; ZA 783493 B 19790627
DOCDB simple family (application)
EP 80106498 A 19780619; AT 448678 A 19780620; AU 3724478 A 19780619; AU 3729878 A 19780620; CA 305798 A 19780620; DK 270278 A 19780615; DK 270378 A 19780615; EP 78100190 A 19780619; EP 78100191 A 19780619; EP 80106497 A 19780619; ES 470912 A 19780619; ES 470913 A 19780619; FI 781954 A 19780619; FI 781955 A 19780619; IE 123478 A 19780619; IT 6844978 A 19780620; IT 6845078 A 19780620; JP 7479978 A 19780620; JP 7480078 A 19780620; NO 782127 A 19780619; NO 782128 A 19780619; NO 792839 A 19790903; NZ 18761578 A 19780619; US 10408079 A 19791217; US 91711878 A 19780619; ZA 783492 A 19780619; ZA 783493 A 19780619