EP 0000355 B1 19820106 - NEW INDOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
Title (en)
NEW INDOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
Publication
Application
Priority
- CH 300878 A 19780320
- CH 858977 A 19770712
Abstract (en)
[origin: EP0000355A1] Indole compounds useful for the treatment of hypertension, of formula <CHEM> wherein n is 2 or 3, A is 1,4-cyclohexylidene or trimethylene and R1 is H or alkyl, or A together with NR1 is 4-piperidyl, R2 is hydrogen or alkyl, R3 is alkyl, cycloalkyl, amino, alkylamino, dialkylamino, phenylamino, unsubstituted or substituted phenyl or benzyl, pyridylmethyl or an heterocycle, R4 is hydrogen, chlorine, bromine or alkyl, R5 is hydrogen, alkyl, alkoxy or alkylthio, and X is -CO- or -CS, a process for their production which comprises a) acylating a compound of formula II <CHEM> wherein n, A and R1 to R5 are as defined above, or b) condensing a compound of formula III <CHEM> wherein n, R4 and R5 are as defined above, and Y is a leaving group, with a compound of formula IV <CHEM> wherein A, R1 to R3 and X are as defined above. n
IPC 1-7
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/445 (2006.01); A61K 31/495 (2006.01); A61P 9/12 (2006.01); C07D 209/14 (2006.01); C07D 209/16 (2006.01); C07D 209/18 (2006.01); C07D 209/30 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP)
A61P 9/12 (2018.01); C07D 209/14 (2013.01); C07D 209/16 (2013.01); C07D 209/18 (2013.01)
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0000355 A1 19790124; EP 0000355 B1 19820106; AU 3793978 A 19800117; AU 521641 B2 19820422; CA 1114381 A 19811215; DE 2861502 D1 19820225; DK 300978 A 19790113; ES 471593 A1 19791001; FI 782138 A 19790113; IE 47209 B1 19840111; IE 781382 L 19790112; IL 55116 A0 19780929; IL 55116 A 19820228; IT 7850140 A0 19780703; JP S5436259 A 19790316; NZ 187813 A 19810316; PH 14993 A 19820322; PT 68270 A 19780801
DOCDB simple family (application)
EP 78100274 A 19780629; AU 3793978 A 19780711; CA 307174 A 19780711; DE 2861502 T 19780629; DK 300978 A 19780703; ES 471593 A 19780710; FI 782138 A 19780703; IE 138278 A 19780710; IL 5511678 A 19780710; IT 5014078 A 19780703; JP 8363778 A 19780711; NZ 18781378 A 19780710; PH 21359 A 19780612; PT 6827078 A 19780710