EP 0000383 B1 19821013 - PYRIMIDO (4,5-C) PYRIDAZINES, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESS FOR THEIR PREPARATION
Title (en)
PYRIMIDO (4,5-C) PYRIDAZINES, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESS FOR THEIR PREPARATION
Publication
Application
Priority
GB 2876577 A 19770708
Abstract (en)
[origin: EP0000383A1] Pyrimido (4,5-c) pyridazines of formula II and compounds of formulae III, IV, VI, VII, VIII. <CHEM> wherein R<1> is alkyl hydroxymethyl, phenyl, carboxy, optionally substituted benzyl, optionally substituted phenacyl, acyloxymethyl, indolyl, indolyl methyl, a group CH(CN)CH2C6H5 optionally substituted in the phenyl ring, a group CH(Y)CO2Z or a group CH2CH2CO2Z in which Y is hydrogen, alkyl or alkoxy, and Z is hydrogen or alkyl, are inhibitors of dihydropteroic acid biosynthesis and have anti-microbial activity. They can be prepared as follows: <CHEM>
IPC 1-7
IPC 8 full level
A61K 31/505 (2006.01); A61P 43/00 (2006.01); C07D 239/48 (2006.01); C07D 239/50 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP US)
A61P 43/00 (2017.12 - EP); C07D 239/48 (2013.01 - EP US); C07D 239/50 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US)
Designated contracting state (EPC)
CH DE FR GB
DOCDB simple family (publication)
EP 0000383 A1 19790124; EP 0000383 B1 19821013; DE 2862102 D1 19821118; JP S5419996 A 19790215; JP S6339597 B2 19880805; US 4225710 A 19800930; US 4302587 A 19811124; US 4303789 A 19811201; US 4303790 A 19811201; US 4323679 A 19820406; US 4329362 A 19820511
DOCDB simple family (application)
EP 78100331 A 19780707; DE 2862102 T 19780707; JP 8286978 A 19780707; US 14925580 A 19800513; US 15305880 A 19800527; US 15305980 A 19800527; US 15306080 A 19800527; US 15306180 A 19800527; US 92254578 A 19780707