EP 0000452 B1 19810506 - 1,2,4-OXADIAZOL DERIVATIVES, THEIR PREPARATION AND APPLICATION IN PHARMACEUTICAL COMPOSITIONS
Title (en)
1,2,4-OXADIAZOL DERIVATIVES, THEIR PREPARATION AND APPLICATION IN PHARMACEUTICAL COMPOSITIONS
Publication
Application
Priority
- FR 7721447 A 19770712
- FR 7817114 A 19780608
Abstract (en)
[origin: ES478527A1] 1,2,4-Oxadiazole derivatives of the formula < IMAGE > (I) wherein R1, R2, R3, R4 and R5=H, halogen or alkyl, or two of them represent the -CH=CH-CH=CH- group required to form a fused benzene ring and R=an amino radical NR'R'' or -N=CR'3-NR'1R'2, in which R', R'', R'1 and R'2=alkyl, hydroxyalkyl or N,N-dialkylaminoalkyl or NRR' or NR'1R'2=heterocyclic ring, and R' R'' can also be H, dialkylaminoalkylcarbonyl and pyridinoalkyl, (at least two of R1 to R5 being other than H when R' and R''=H), are pharmaceutically useful as anti-hypertensive agents.
IPC 1-7
C07D 271/06; C07D 403/12; C07D 401/12; C07D 403/04; A61K 31/41
IPC 8 full level
A61K 31/415 (2006.01); A61K 31/4245 (2006.01); A61P 9/12 (2006.01); C07C 67/00 (2006.01); C07C 325/00 (2006.01); C07C 333/26 (2006.01); C07D 271/07 (2006.01); C07D 271/06 (2006.01)
CPC (source: EP US)
A61P 9/12 (2018.01 - EP); C07D 271/07 (2013.01 - EP US)
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0000452 A1 19790124; EP 0000452 B1 19810506; AR 222310 A1 19810515; AT 362367 B 19810511; AT A505378 A 19801015; AU 3790978 A 19800117; AU 515506 B2 19810409; CA 1130806 A 19820831; DE 2860691 D1 19810813; DK 307378 A 19790113; ES 471609 A1 19790916; ES 478527 A1 19790516; FI 782220 A 19790113; GR 64924 B 19800609; IL 55104 A0 19780929; IL 55104 A 19820730; IT 1096906 B 19850826; IT 7825497 A0 19780710; JP S5419978 A 19790215; JP S5834473 B2 19830727; NO 782404 L 19790115; NZ 187825 A 19800305; PT 68267 A 19780801; US 4242352 A 19801230; US 4261994 A 19810414
DOCDB simple family (application)
EP 78400026 A 19780620; AR 27293078 A 19780712; AT 505378 A 19780712; AU 3790978 A 19780710; CA 307090 A 19780710; DE 2860691 T 19780620; DK 307378 A 19780707; ES 471609 A 19780711; ES 478527 A 19790312; FI 782220 A 19780711; GR 780156739 A 19780710; IL 5510478 A 19780707; IT 2549778 A 19780710; JP 8501778 A 19780711; NO 782404 A 19780710; NZ 18782578 A 19780710; PT 6826778 A 19780710; US 3419779 A 19790427; US 92252778 A 19780707