EP 0000453 B1 19800723 - PROCESS FOR THE PREPARATION OF THIENOPYRIDINE DERIVATIVES.
Title (en)
PROCESS FOR THE PREPARATION OF THIENOPYRIDINE DERIVATIVES.
Publication
Application
Priority
FR 7721517 A 19770712
Abstract (en)
[origin: ES471403A1] This invention relates to a process for the preparation of compounds having the general formula: < IMAGE > (I) in which: R1 represents a hydrogen atom, an optionaly substituted alkyl, aryl or aralkyl radical R2 and R3 are the same or different and represent independently a hydrogen atom, a lower alkyl, aryl or heterocyclic radical and R4 represents a hydrogen atom or an alkyl, cycloalkyl, alkoxy carbonyl, carboxy, aryl or heterocyclic radical, comprising reacting a compound having the formula: < IMAGE > (II) in which R1, R2 and R3 are as defined above, with a compound having the formula: < IMAGE > (III) in which R4 is as defined above X is a halogen atom, or an optionally substituted alkoxy, thioalkyl or amino group and Y represents an optionally substituted alkoxy, thioalkyl or amino group, or a group of the formula: < IMAGE > in which R is a lower alkyl or aryl radical or both the groups X and Y, together with the carbon atom to which they are attached, form a 6-membered hexahydro-S-triazinic, trioxannic or trithianic heterocyclic nucleus, in an inert solvent, at a temperature between 0 DEG and 150 DEG C. and in an anhydrous medium, and, if desired, liberating the free base.
IPC 1-7
IPC 8 full level
A61K 31/4365 (2006.01); C07D 333/16 (2006.01); C07D 333/36 (2006.01); C07D 495/04 (2006.01); C07D 513/04 (2006.01)
CPC (source: EP US)
C07C 323/00 (2013.01 - EP US); C07D 333/16 (2013.01 - EP US); C07D 495/04 (2013.01 - EP US); Y02P 20/582 (2015.11 - EP US)
Designated contracting state (EPC)
DE NL SE
DOCDB simple family (publication)
EP 0000453 A1 19790124; EP 0000453 B1 19800723; AR 224501 A1 19811215; AT 366691 B 19820426; AT A468978 A 19810915; AU 3794078 A 19800117; AU 516506 B2 19810604; BE 868866 A 19790110; CA 1113469 A 19811201; CH 633013 A5 19821115; DD 136838 A5 19790801; DE 2860056 D1 19801113; DK 155285 B 19890320; DK 155285 C 19890724; DK 311078 A 19790113; ES 471403 A1 19790116; FI 67852 B 19850228; FI 67852 C 19850610; FI 782044 A 19790113; FR 2397417 A1 19790209; FR 2397417 B1 19800418; GB 1599728 A 19811007; GR 64796 B 19800602; HU 181928 B 19831128; IE 46929 B1 19831102; IE 781155 L 19790112; IL 54886 A0 19780831; IL 54886 A 19811130; IT 1105084 B 19851028; IT 7850225 A0 19780710; JP S5419994 A 19790215; JP S6339598 B2 19880805; LU 79823 A1 19781207; MX 4884 E 19821202; NO 152844 B 19850819; NO 152844 C 19851127; NO 782411 L 19790115; NZ 187834 A 19810501; PH 14288 A 19810504; PL 115368 B1 19810331; PL 208318 A1 19790507; PT 68251 A 19780801; RO 74931 A 19801030; SU 900813 A3 19820123; US 4174448 A 19791113; YU 148278 A 19820831; YU 41832 B 19880229; ZA 783296 B 19790725
DOCDB simple family (application)
EP 78400029 A 19780621; AR 27289978 A 19780711; AT 468978 A 19780628; AU 3794078 A 19780711; BE 189175 A 19780710; CA 307086 A 19780710; CH 616778 A 19780606; DD 20665178 A 19780711; DE 2860056 T 19780621; DK 311078 A 19780711; ES 471403 A 19780704; FI 782044 A 19780627; FR 7721517 A 19770712; GB 2420978 A 19780530; GR 780156589 A 19780624; HU PA001325 A 19780711; IE 115578 A 19780607; IL 5488678 A 19780609; IT 5022578 A 19780710; JP 8498378 A 19780712; LU 79823 A 19780615; MX 721678 U 19780710; NO 782411 A 19780711; NZ 18783478 A 19780711; PH 21363 A 19780712; PL 20831878 A 19780711; PT 6825178 A 19780704; RO 9458478 A 19780706; SU 2632645 A 19780710; US 91307378 A 19780606; YU 148278 A 19780613; ZA 783296 A 19780608