EP 0000518 B1 19810107 - PROCESS FOR THE CHEMICAL RESOLUTION OF RACEMIC MANDELIC ACID, AND THE SALT OF D(-)-2- AMINOBUTANOL-(1) WITH D(-)-MANDELIC ACID
Title (en)
PROCESS FOR THE CHEMICAL RESOLUTION OF RACEMIC MANDELIC ACID, AND THE SALT OF D(-)-2- AMINOBUTANOL-(1) WITH D(-)-MANDELIC ACID
Publication
Application
Priority
DE 2733425 A 19770723
Abstract (en)
[origin: EP0000518A1] 1. Process for the chemical cleavage of racemic mandelic acid and for the preparation especially of D(-)-mandelic acid, which comprises reacting DL-mandelic acid in one solvent or in a mixture of several solvents of the group water, lower aliphatic alcohols and ketones with D(-)-2-aminobutanol-(1), separating the crystallizing diastereomeric salt from the mother liquor and subsequently splitting according to known methods the diastereomeric salts contained in the crystallization product and the mother liquor with acids or bases to yield each the optically active acids and D(-)-2-aminobutanol-(1).
IPC 1-7
IPC 8 full level
C07B 31/00 (2006.01); C07B 57/00 (2006.01); C07C 51/00 (2006.01); C07C 59/50 (2006.01); C07C 67/00 (2006.01); C07C 213/00 (2006.01); C07C 215/08 (2006.01)
CPC (source: EP)
C07C 59/50 (2013.01)
Citation (examination)
- BE 827580 A 19750731
- DE 687555 C 19400206 - CHEM FAB VORMALS SANDOZ
- DE 1243206 C
- US 3686183 A 19720822 - DYSON NORMAN H
- GB 1266723 A 19720315
- AT 334345 B 19760110 - PLIVA PHARM & CHEM WORKS [YU]
- FR 1439850 A 19660527 - ZOJA LAB CHIM FARM
- J.Am.Chem.Soc. 55(1933), 411-416
- Houben-Weyl, Methoden der organischen Chemie, Band 4/2 (1955) S. 522
- A.Am.Chem.Soc. 51(1929), 1906-1909
- Acta Chem. Scand. 16 (1962), 591-598
- J.Amer.Soc. 76 (1954), 2801-2803
- Chimia 23 (1969), 399-400
- S.H. Wilen, Topics in Stereochemistry 6 (1971), 114
Designated contracting state (EPC)
BE CH DE FR GB NL
DOCDB simple family (publication)
EP 0000518 A1 19790207; EP 0000518 B1 19810107; DE 2733425 A1 19790125; DE 2733425 C2 19820826; DE 2860412 D1 19810226; JP S5424849 A 19790224; JP S5843939 A 19830314
DOCDB simple family (application)
EP 78100393 A 19780714; DE 2733425 A 19770723; DE 2860412 T 19780714; JP 10668582 A 19820623; JP 8851378 A 19780721