EP 0000533 B1 19810805 - N-SUBSTITUTED 9,10-DIHYDROLYSERGIC ACID ESTERS AND A METHOD FOR THEIR PREPARATION
Title (en)
N-SUBSTITUTED 9,10-DIHYDROLYSERGIC ACID ESTERS AND A METHOD FOR THEIR PREPARATION
Publication
Application
Priority
YU 181977 A 19770721
Abstract (en)
[origin: ES471716A1] A process for the preparation of N-substituted esters of 9,10-dihydrolysergic acids of the formula: < IMAGE > (I) wherein R1 is an alkyl group of 1-5 carbon atoms, an alkenyl group of 2-5 carbon atoms or a cycloalkyl group of 3-5 carbon atoms, R2 is hydrogen or an alkoxy group of 1-3 carbon atoms and X' is hydrogen or halogen, characterized in that esterified 9,10-dihydrolysergic acids of the formula: < IMAGE > (II) wherein R is hydrogen or a hydrolyzable organic group, X' is hydrogen or halogen, and R2 has the meaning as stated above, are reacted with a compound of the formula: R1Y (III) wherein R1 has the meaning as stated above, Y is halogen or sulphate, in the presence of a catalyst for phase transition in the presence of aqueous alkali medium in an inert organic solvent immiscible with water, and certain novel esters obtained thereby.
IPC 1-7
IPC 8 full level
C07D 457/02 (2006.01); A61K 31/48 (2006.01); B01J 31/00 (2006.01); C07B 61/00 (2006.01); C07D 457/04 (2006.01)
CPC (source: EP US)
C07D 457/04 (2013.01 - EP US)
Designated contracting state (EPC)
BE CH DE FR GB SE
DOCDB simple family (publication)
EP 0000533 A1 19790207; EP 0000533 B1 19810805; AT 363195 B 19810710; AT A490078 A 19801215; CS 216231 B2 19821029; DE 2860896 D1 19811105; ES 471716 A1 19791001; FI 64369 B 19830729; FI 64369 C 19831110; FI 782081 A 19790122; JP S5436296 A 19790316; JP S5648512 B2 19811116; PT 68278 A 19780801; SU 784775 A3 19801130; US 4230859 A 19801028; YU 181977 A 19830121; YU 40004 B 19850630
DOCDB simple family (application)
EP 78100419 A 19780718; AT 490078 A 19780706; CS 479078 A 19780718; DE 2860896 T 19780718; ES 471716 A 19780714; FI 782081 A 19780629; JP 8850978 A 19780721; PT 6827878 A 19780712; SU 2637592 A 19780720; US 92269278 A 19780707; YU 181977 A 19770721