EP 0000546 A1 19790207 - D-homo oxasteroids, processes for their preparation, their use in preparing pharmaceutical compositions with antiinflammatocy activity and pharmaceutical compositions containing them.
Title (en)
D-homo oxasteroids, processes for their preparation, their use in preparing pharmaceutical compositions with antiinflammatocy activity and pharmaceutical compositions containing them.
Title (de)
D-Homo-Oxasteroide, Verfahren zu ihrer Herstellung und ihre Anwendung zur Herstellung von pharmazeutischen Zusammensetzungen mit antiinflammatorischer Aktivität, sowie diese enthaltene pharmazeutische Zusammensetzungen.
Title (fr)
D-homo-oxastéroides, procédés pour leur préparation et leur utilisation dans la préparation des compositions pharmaceutiques avec activité anti-inflammatoire et compositions pharmaceutiques les contenant.
Publication
Application
Priority
US 81731577 A 19770720
Abstract (en)
[origin: US4116978A] D-Homo oxasteroids and processes for their preparation, which can be used as anti-inflammatory agents, the steroids having the formula <CHEM> or the 1,2-dehydro derivative thereof; wherein R1 is hydrogen, alkyl-@-O-, aryl-@-O-, halogen or hydroxy; R2is hydrogen or alkyl; R3 is alkyl; R4 is carbonyl, beta -hydroxymethylene, beta -chloromethylene or beta -bromomethylene; R5 is hydrogen, fluorine, chlorine or bromine; R6 is hydrogen, fluorine or methyl; and R7 is hydrogen, chlorine or bromine; with the proviso that when R1 is hydroxy, R2 is alkyl; and with the further proviso that when R2 is alkyl, it is the same alkyl group as R3; wherein aryl is phenyl or phenyl substituted with one or two alkyl, alkoxy or halogen groups; and alkyl and alkoxy are groups having 1 to 10 carbon atoms.
IPC 1-7
IPC 8 full level
A61K 31/35 (2006.01); A61K 31/352 (2006.01); C07D 311/78 (2006.01); A61P 29/00 (2006.01); C07J 73/00 (2006.01)
CPC (source: EP US)
A61P 29/00 (2018.01 - EP); C07J 73/003 (2013.01 - EP US)
Citation (search report)
FR 1490967 A 19670804 - SQUIBB & SONS INC
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
US 4155917 A 19790522; AU 3777478 A 19800110; AU 517482 B2 19810806; CA 1113925 A 19811208; EP 0000546 A1 19790207; IT 1097826 B 19850831; IT 7825879 A0 19780719; JP S5422356 A 19790220; US 4116978 A 19780926
DOCDB simple family (application)
US 91601678 A 19780615; AU 3777478 A 19780705; CA 306430 A 19780628; EP 78100445 A 19780719; IT 2587978 A 19780719; JP 8926978 A 19780720; US 81731577 A 19770720