EP 0000574 B1 19820804 - BENZIMIDAZOLE-2 DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS
Title (en)
BENZIMIDAZOLE-2 DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS
Publication
Application
Priority
- CH 209478 A 19780227
- HU CI001761 A 19770801
Abstract (en)
[origin: ES472208A1] Novel substituted heterocyclyl compounds of the formula < IMAGE > (I) in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R1-X, and X is lower alkylidene or a direct bond, and pharmaceutically usable salts of compounds of the formula I with salt-forming properties as medicaments, pharmaceutical preparations containing these, their use as medicaments and also novel compounds of the formula I and salts of compounds of the formula I with salt-forming properties, with the proviso that R1-X-Ph differs from 1,2-phenylene substituted by methyl in the 4- and/or 5-position when R is carboxyl, carbamyl or hydroxymethyl and R2 is hydrogen, and pharmaceutically acceptable salts thereof are useful as anti-allergic agents.
IPC 1-7
C07D 235/24; C07D 235/12; C07D 405/00; C07D 409/00; C07D 401/00; A61K 31/415; C07C 49/80; C07C 87/58; C07C 49/76; C07C 87/52
IPC 8 full level
A61K 31/415 (2006.01); A61K 31/4184 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07C 45/46 (2006.01); C07D 235/12 (2006.01); C07D 235/16 (2006.01); C07D 235/24 (2006.01); C07D 235/32 (2006.01); C07D 405/02 (2006.01)
CPC (source: EP US)
A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 45/46 (2013.01 - EP US); C07C 205/45 (2013.01 - EP US); C07D 235/12 (2013.01 - EP US); C07D 235/24 (2013.01 - EP US)
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0000574 A1 19790207; EP 0000574 B1 19820804; AR 223196 A1 19810731; AR 227125 A1 19820930; AR 228023 A1 19830114; AR 231636 A1 19850131; AT 364830 B 19811125; AT A553978 A 19810415; AU 3847878 A 19800207; AU 523324 B2 19820722; CA 1109072 A 19810915; DD 138318 A5 19791024; DE 2861987 D1 19820930; DK 339578 A 19790202; ES 472208 A1 19790316; FI 68231 B 19850430; FI 68231 C 19850812; FI 782348 A 19790202; GR 77614 B 19840925; IE 47285 B1 19840208; IE 781545 L 19790201; IL 55253 A0 19780929; IL 55253 A 19820430; JP S5427565 A 19790301; NO 150082 B 19840507; NO 150082 C 19840815; NO 782615 L 19790202; NZ 188006 A 19811119; PL 208772 A1 19790604; PT 68365 A 19780801; US 4323688 A 19820406
DOCDB simple family (application)
EP 78100489 A 19780724; AR 27314578 A 19780731; AR 27884979 A 19791112; AR 27885179 A 19791112; AR 27885379 A 19791112; AT 553978 A 19780731; AU 3847878 A 19780731; CA 308351 A 19780728; DD 20700978 A 19780728; DE 2861987 T 19780724; DK 339578 A 19780731; ES 472208 A 19780731; FI 782348 A 19780728; GR 780156880 A 19780727; IE 154578 A 19780731; IL 5525378 A 19780731; JP 9322478 A 19780801; NO 782615 A 19780731; NZ 18800678 A 19780731; PL 20877278 A 19780801; PT 6836578 A 19780731; US 92863278 A 19780727