Title (en)

Intravascularly-administrable, magnetically-localizable biodegradable carrier and process for its preparation.

Title (de)

Intravascular verabreichbarer, magnetisch lokalisierbarer biologisch abbaubarer Substanzträger und Verfahren zu ihrer Herstellung.

Title (fr)

Véhicule biodégradable pouvant être localisé par magnétisme et administré par voie intravasculaire ainsi qu'un procédé pour sa préparation.

Publication

EP 0000667 A1 19790207 (EN)

Application

EP 78300208 A 19780728

Priority

• US 82081277 A 19770801
• US 85984277 A 19771212

Abstract (en)

[origin: CA1109792A] The intravascularly-administrable, magnetically-local-izable biodegradable carrier comprises microspheres formed from an amino acid polymer matrix with magnetic particles embedded therein. The microspheres can be used for intra-arterial administration and capillary level localization and/or release of therapeutic and diagnostic agents, thereby obtaining much more precise targeting of the agents than has heretofore been possible. Also a process is provided for incorporating water-sol uble therapeutic agents in albumin microspheres. This process is particularly advantageous where the therapeutic agent is heatsensitive. All steps of the process can be carried out at relatively low temperatures, such as ambient room temperature. The process may be applied to the preparation or the above mentioned intravascularly-administrable, magnetically-responsive microspheres.

IPC 1-7

A61K 9/50; A61K 9/00; A61K 9/52

IPC 8 full level

A61K 47/42 (2006.01); A61K 9/107 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/64 (2006.01); A61K 41/00 (2006.01); A61K 47/02 (2006.01); A61K 49/18 (2006.01)

CPC (source: EP US)

A61K 9/1641 (2013.01 - EP US); A61K 9/1658 (2013.01 - EP US); A61K 9/5094 (2013.01 - EP US); A61K 41/0052 (2013.01 - EP US); A61K 49/1821 (2013.01 - EP US); A61K 49/1869 (2013.01 - EP US); A61K 49/1887 (2013.01 - EP US); B82Y 5/00 (2013.01 - EP US); G01N 2333/765 (2013.01 - EP US); G01N 2446/20 (2013.01 - EP US); G01N 2446/30 (2013.01 - EP US)

Citation (search report)

• US 3474777 A 19691028 - FIGGE FRANK H J, et al
• [D] US 3937668 A 19760210 - ZOLLE ILSE
• GB 929401 A 19630619 - UPJOHN CO
• [A] FR 2326934 A1 19770506 - MINNESOTA MINING & MFG [US]
• [A] FR 1468601 A 19670210 - NCR CO
• [A] FR 1351358 A 19640207 - NCR CO
• [A] US 3725113 A 19730403 - CHANG T
• [A] US 3190837 A 19650622 - CARL BRYNKO, et al
• [A] US 3057344 A 19621009 - ALBERTO ABELLA CARLOS, et al
• [A] US 2971916 A 19610214 - LOWELL SCHLEICHER, et al
• [A] US 2671451 A 19540309 - BOLGER STEPHEN J
• [A] NL 280825 A
• [A] NL 280826 A
• CHEMICAL ABSTRACTS, vol. 80, no. 5, March 11, 1974. Columbus, Ohio, (USA) TAKAI et al: "Coated magnetic powder"; & JP-B-48 024 246 (TDK ELECTRONICS) page 298, abstract no. 52392a

Designated contracting state (EPC)

BE CH DE FR GB NL

DOCDB simple family (publication)

EP 0000667 A1 19790207; EP 0000667 B1 19830706; CA 1109792 A 19810929; DE 2862289 D1 19830811; IE 47305 B1 19840222; IE 781540 L 19790201; IT 1097568 B 19850831; IT 7826375 A0 19780801; JP S5464626 A 19790524; JP S5649889 B2 19811125; US 4357259 A 19821102

DOCDB simple family (application)

EP 78300208 A 19780728; CA 308471 A 19780731; DE 2862289 T 19780728; IE 154078 A 19780731; IT 2637578 A 19780801; JP 9446978 A 19780801; US 85984277 A 19771212