EP 0000667 B1 19830706 - INTRAVASCULARLY-ADMINISTRABLE, MAGNETICALLY-LOCALIZABLE BIODEGRADABLE CARRIER AND PROCESS FOR ITS PREPARATION
Title (en)
INTRAVASCULARLY-ADMINISTRABLE, MAGNETICALLY-LOCALIZABLE BIODEGRADABLE CARRIER AND PROCESS FOR ITS PREPARATION
Publication
Application
Priority
- US 82081277 A 19770801
- US 85984277 A 19771212
Abstract (en)
[origin: CA1109792A] The intravascularly-administrable, magnetically-local-izable biodegradable carrier comprises microspheres formed from an amino acid polymer matrix with magnetic particles embedded therein. The microspheres can be used for intra-arterial administration and capillary level localization and/or release of therapeutic and diagnostic agents, thereby obtaining much more precise targeting of the agents than has heretofore been possible. Also a process is provided for incorporating water-sol uble therapeutic agents in albumin microspheres. This process is particularly advantageous where the therapeutic agent is heatsensitive. All steps of the process can be carried out at relatively low temperatures, such as ambient room temperature. The process may be applied to the preparation or the above mentioned intravascularly-administrable, magnetically-responsive microspheres.
IPC 1-7
IPC 8 full level
A61K 47/42 (2006.01); A61K 9/107 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/64 (2006.01); A61K 41/00 (2006.01); A61K 47/02 (2006.01); A61K 49/18 (2006.01)
CPC (source: EP US)
A61K 9/1641 (2013.01 - EP US); A61K 9/1658 (2013.01 - EP US); A61K 9/5094 (2013.01 - EP US); A61K 41/0052 (2013.01 - EP US); A61K 49/1821 (2013.01 - EP US); A61K 49/1869 (2013.01 - EP US); A61K 49/1887 (2013.01 - EP US); B82Y 5/00 (2013.01 - EP US); G01N 2333/765 (2013.01 - EP US); G01N 2446/20 (2013.01 - EP US); G01N 2446/30 (2013.01 - EP US)
Citation (examination)
- Proc. Soc. Exo. Biol. and Med. 58, 141-146 (1978)
- J. Pharm. Sci. 68, 79-81 (1979)
Designated contracting state (EPC)
BE CH DE FR GB NL
DOCDB simple family (publication)
EP 0000667 A1 19790207; EP 0000667 B1 19830706; CA 1109792 A 19810929; DE 2862289 D1 19830811; IE 47305 B1 19840222; IE 781540 L 19790201; IT 1097568 B 19850831; IT 7826375 A0 19780801; JP S5464626 A 19790524; JP S5649889 B2 19811125; US 4357259 A 19821102
DOCDB simple family (application)
EP 78300208 A 19780728; CA 308471 A 19780731; DE 2862289 T 19780728; IE 154078 A 19780731; IT 2637578 A 19780801; JP 9446978 A 19780801; US 85984277 A 19771212