Global Patent Index - EP 0000816 A1

EP 0000816 A1 19790221 - Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.

Title (en)

Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.

Title (de)

Substituierte Aminopyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.

Title (fr)

Dérivés substitués d'aminopyridines, leurs procédés de préparation et compositions pharmaceutiques les contenant.

Publication

EP 0000816 A1 19790221 (EN)

Application

EP 78300190 A 19780725

Priority

  • GB 1940678 A 19780513
  • GB 3305577 A 19770806

Abstract (en)

A class of substituted amino pyridine derivatives are of value in the treatment of diabetes. Some of the compounds also possess hypolipidaemic activity. The compounds are represented by the formula (I): <CHEM> wherein R<3> is hydrogen, alkyl or an acidic function; R<2> is hydrogen or alkyl; R<4> and R<5> are hydrogen, alkyl or halogen; Z is hydrogen, phenyl, alkyl or aralkyl; Alk is alkylene and x is 0 or 1; R<1> is optionally substituted phenyl or naphthyl. Most of the compounds of formula (I) are novel.

IPC 1-7

C07D 213/74; A61K 31/44; A61K 31/455; C07D 213/80; C07D 213/85; C07D 401/04

IPC 8 full level

A61K 31/44 (2006.01); A61K 31/455 (2006.01); C07D 213/74 (2006.01); C07D 213/80 (2006.01); C07D 213/85 (2006.01); C07D 401/04 (2006.01)

CPC (source: EP)

A61K 31/44 (2013.01); A61K 31/455 (2013.01); C07D 213/74 (2013.01); C07D 213/80 (2013.01); C07D 213/85 (2013.01)

Citation (search report)

  • [X] NL 6707290 A 19671129
  • [X] GB 1420987 A 19760114 - CASSELLA FARBWERKE MAINKUR AG
  • [X] GB 1191302 A 19700513 - DEGUSSA [DE]
  • [X] NL 6511104 A 19660301
  • [X] DE 2141418 A1 19720309
  • [X] DE 1119274 B 19611214 - RASCHIG GMBH DR F
  • [X] US 3450707 A 19690617 - BAILEY DENIS M
  • [X] GB 1270363 A 19720412 - RHONE POULENC SA [FR]
  • [X] GB 1405308 A 19750910 - BASF AG
  • [X] FR 2340934 A1 19770909 - BASF AG [DE]
  • [X] US 2784138 A 19570305 - RICHARD WEGLER, et al
  • [X] FR 2288798 A1 19760521 - POPESCU FRANCINE [FR]
  • [X] US 3535328 A 19701020 - ZIELINSKI JAMES
  • [X] FR 2155922 A2 19730525 - ARIES ROBERT
  • [X] CHEMICAL ABSTRACTS, vol. 86 (1977) p. 100, 84340x, L.G. GRIFFIS et al: "The acute toxicity of 2 benzylaminopyridine"; & TOXICOL. APPL. PHARMACOL., 1976, 38(3) 639-41
  • [X] DIE PHARMAZIE, 32 (3) 1977, Berlin, P. 149-50, A.H. ABO-SIER et al: "Synthesis of some 3,4,5-trimethoxybenzylderivatives of certain amino compounds likely to possess CNS activity"
  • [X] CHEMICAL ABSTRACTS, vol. 83, 1975, 96954b, p. 553, J. DELARGE: "Synthesis of nonstero{dal antiinflammatory substances"; & MEM. ACAD. R. MED. BELG., 1974, 47 (3), 131-120, Abstract; Chemical Abstracts 9th Collect. Chemical Substances Index 9CS21, p. 33816 CS
  • [X] BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1975, (3-4) P. 576-82, M. DOME et al: "No. 108 Alkylations en milieu aqueux par les halogénures aminés ou amidés. II Réactions avec quelques nucléophiles"
  • IL FARMACO, EDIZIONE SCIENTIFICA, 31 (1976) (2) p. 105-11, G. BETTONI et al: "Determinazione della confrigurazione assoluta di composti amminici aventi interesse farmaceutico attraverso misure di dicroismo circolare"
  • [X] CHEMICAL ABSTRACTS, vol. 53 (1959) 18951c, H. FUESRT et al: "Alkylamino pyridines and alkyl pyridine ethers"
  • [X] CHEMICAL ABSTRACTS, vol. 87 (1977), p. 544, 117193c, G. BETTONI et al: "The chiroptical properties of some substituted N-(pyridyl) derivatives of amines"; & GAZZ. CHIM. ITAL. 1977, 107(1-2), 111-16
  • [X] CHEMISCHE BERICHTE, 109, (1976) p. 3661-7, W. STADLBAUER et al: "Syntheses mesoionischer S-Triazine"
  • [X] BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 49, (10), 1976, p. 2770-74, Y. TAKAHASHI et al: "Studies on the tantomerism of 2-anilinopyridine and related heterocycles"
  • [X] TETRAHEDRON, Pergamon Press (1973), 29(2), p. 419-24, S.V. KESSAR et al: "New routes to condensed polynuclear compounds IX"
  • CHEMICAL ABSTRACTS, vol. 82 (1975), p. 446, 16223d, TORTORELLA V. et al: "Influence of additional aromatic chromophores on the chiroptical properties of N- (2 pyridyl N-oxide) amino derivatives"; & GAZZ. CHIM. ITAL. 1973, 103 (10-12), 1083-98, Abstracts chemical abstracts, 9th collective index, chemical substances 9CS20, p. 33543, CS-33549 CS.
  • TETRAHEDRON, Pergamon Press 1973, vol. 29, p. 1345-52, V. TORTORELLA et al: "NMR-Investigation on the conformational properties of N-(2-pyridyl-N-oxide)-amino derivatives.

Designated contracting state (EPC)

BE CH DE FR GB NL SE

DOCDB simple family (publication)

EP 0000816 A1 19790221; AU 3862078 A 19800207; DK 346278 A 19790207; ES 472384 A1 19791001; ES 479931 A1 19791201; ES 479932 A1 19791201; ES 479933 A1 19791201; IL 55242 A0 19780929; IT 1106623 B 19851111; IT 7850601 A0 19780804; JP S5441881 A 19790403

DOCDB simple family (application)

EP 78300190 A 19780725; AU 3862078 A 19780803; DK 346278 A 19780804; ES 472384 A 19780804; ES 479931 A 19790425; ES 479932 A 19790425; ES 479933 A 19790425; IL 5524278 A 19780728; IT 5060178 A 19780804; JP 9604778 A 19780807