EP 0000825 B1 19820414 - GEMINALLY DISUBSTITUTED INDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Title (en)
GEMINALLY DISUBSTITUTED INDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Publication
Application
Priority
GB 3294777 A 19770805
Abstract (en)
[origin: ES472291A1] New geminally disubstituted indenes are of general formula I < IMAGE > (I) wherein each of R1 and R2 is hydrogen or R1 and R2 together form a direct bond or an alkylene group -(CH2)n-, in which n is an integer from 1 to 4, R3 is hydrogen, C1-3-alkoxy or halogen, and each of R4 and R5 is hydrogen or C1-4-lower alkyl, or R4 and R5 together form an alkylene group -(CH2)m-, in which m is an integer from 3 to 6 and the corresponding amine oxides, quaternary ammonium compounds and salts with physiologically acceptable acids. The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as vasocostrictor or as an anti-reserpine agent. The indenes may be prepared by processes known per se involving (a) synthesing the side chain -CH(OH)CH2NR4R5 by a method known per se in an indenyl precursor of a formula I compound in which the side chain is incomplete or (b) introducing the double bond into an indanyl precursor of a formula I compound in which the double bond is absent or (c) releasing the terminal amino group in a precursor of a formula I compound in which the terminal amino group is protected.
IPC 1-7
C07C 91/23; C07C 93/14; C07C 135/02; A61K 31/135; C07D 295/08
IPC 8 full level
A61K 31/14 (2006.01); A61K 31/40 (2006.01); A61K 31/445 (2006.01); A61P 9/00 (2006.01); A61P 9/12 (2006.01); A61K 31/135 (2006.01); A61P 25/02 (2006.01); A61P 25/26 (2006.01); C07C 17/10 (2006.01); C07C 47/453 (2006.01); C07C 67/00 (2006.01); C07C 213/00 (2006.01); C07C 215/38 (2006.01); C07C 215/40 (2006.01); C07C 217/74 (2006.01); C07C 291/02 (2006.01); C07C 291/04 (2006.01); C07D 295/08 (2006.01); C07D 295/084 (2006.01)
CPC (source: EP US)
A61P 9/00 (2018.01 - EP); A61P 9/12 (2018.01 - EP); A61P 25/02 (2018.01 - EP); A61P 25/26 (2018.01 - EP); C07C 17/10 (2013.01 - EP US); C07C 47/453 (2013.01 - EP US); C07C 215/38 (2013.01 - EP US); C07C 215/40 (2013.01 - EP US); C07C 217/74 (2013.01 - EP US); C07C 291/02 (2013.01 - EP US); C07D 295/084 (2013.01 - EP US); C07C 2602/08 (2017.05 - EP US); C07C 2603/94 (2017.05 - EP US)
C-Set (source: EP US)
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0000825 A1 19790221; EP 0000825 B1 19820414; AT 367018 B 19820525; AT A563378 A 19811015; AU 3857878 A 19800207; AU 527825 B2 19830324; CA 1109066 A 19810915; DE 2861735 D1 19820527; DK 150538 B 19870323; DK 150538 C 19871012; DK 344778 A 19790206; ES 472291 A1 19790216; FI 71724 B 19861031; FI 71724 C 19870209; FI 782382 A 19790206; IE 47716 B1 19840530; IE 781561 L 19790205; IT 1099587 B 19850918; IT 7826404 A0 19780802; JP S5444651 A 19790409; JP S6344737 B2 19880906; NO 147420 B 19821227; NO 147420 C 19830406; NO 782651 L 19790206; NZ 188037 A 19840706; PT 68383 A 19780901; US 4218472 A 19800819; ZA 784349 B 19790725
DOCDB simple family (application)
EP 78300226 A 19780801; AT 563378 A 19780803; AU 3857878 A 19780802; CA 308533 A 19780801; DE 2861735 T 19780801; DK 344778 A 19780803; ES 472291 A 19780802; FI 782382 A 19780802; IE 156178 A 19780801; IT 2640478 A 19780802; JP 9500278 A 19780803; NO 782651 A 19780802; NZ 18803778 A 19780802; PT 6838378 A 19780803; US 93007378 A 19780801; ZA 784349 A 19780801