EP 0000938 B1 19841017 - MACROMOLECULAR COVALENT CONJUGATES, METHODS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Title (en)
MACROMOLECULAR COVALENT CONJUGATES, METHODS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Publication
Application
Priority
GB 3517377 A 19770822
Abstract (en)
[origin: US4275000A] Macromolecular complexes which comprise a first and a second macromolecular moiety joined by a link derived from a linking agent having two or more reactive groups, one of these reactive groups being an activated acyl group, an isocyanate, an isothiocyanate, an iminoether, an iminothioether or an activated halogen atom attached to an aromatic ring and being capable of reacting with one of the macromolecules from which the macromolecular moieties are derived, under conditions where the remaining reactive group, or groups which is or are each an aziridine ring, an aryl azido group or a halogen atom in an alpha -position relative to a carbonyl group or two carbon atoms removed from a heteroatom carrying a lone pair of electrons, is or are substantially unreactive. Methods are provided for making the complexes and so are uses for the complexes. Pharmaceutical formulations containing the complex as are provided.
IPC 1-7
IPC 8 full level
C08G 18/00 (2006.01); A61K 47/48 (2006.01); C07K 1/107 (2006.01); C08G 18/64 (2006.01); C08G 81/00 (2006.01); C08H 1/00 (2006.01); C12N 11/06 (2006.01); G01N 33/531 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP US)
A61K 47/6889 (2017.08 - EP US); C07K 1/1072 (2013.01 - EP US); C12N 11/06 (2013.01 - EP US); G01N 33/531 (2013.01 - EP US); A61K 39/00 (2013.01 - EP US); Y10S 530/825 (2013.01 - EP US); Y10S 530/866 (2013.01 - EP US)
Designated contracting state (EPC)
CH DE FR GB SE
DOCDB simple family (publication)
EP 0000938 A1 19790307; EP 0000938 B1 19841017; DE 2862449 D1 19841122; IT 1107772 B 19851125; IT 7850797 A0 19780821; JP S5470384 A 19790606; US 4275000 A 19810623
DOCDB simple family (application)
EP 78100717 A 19780821; DE 2862449 T 19780821; IT 5079778 A 19780821; JP 10170778 A 19780821; US 93471078 A 19780821