EP 0000978 A1 19790307 - 7-and 8-substituted -10,11-dihydro-11-oxodibenzo (b,f) thiepin derivatives, their production and their parmaceutical compositions.
Title (en)
7-and 8-substituted -10,11-dihydro-11-oxodibenzo (b,f) thiepin derivatives, their production and their parmaceutical compositions.
Title (de)
7- oder 8-substituierte 10,11-Dihydro-11-oxodibenzo (b,f) thiepinderivate, ihre Herstellung und ihre pharmazeutischen Zusammensetzungen.
Title (fr)
Dérivés de la 10,11-dihydro-11-oxodibenzo (b,f) thiépine substitués en 7-ou 8-, leur préparation et leurs compositions pharmaceutiques.
Publication
Application
Priority
- US 81920077 A 19770726
- US 91721178 A 19780623
Abstract (en)
The invention provides 7- und 8-R-dibenzo[b,f]thiepin derivatives of formula: <CHEM> in which n is 0 or an integer from 1 to 4; Z is thio, sulfinyl, or sulfonyl; R is hydrogen, halogen, amino, C1-4 alkyl, C1-4 alkanoyl, hydroxyl, C1-4 alkoxy, mercapto, C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, trifluormethyl, trifluoromethylthio, cyano, carboxy, nitro, C1-4 alkylamino or di(C1-4 alkyl)amino; A is 5-tetrazolyl, 3-hydroxy-1,2,5-thiadiazol-4-yl,4-hydroxy-2,5-dioxo- @<3>-pyrrolin-3-yl or -@-R2 where R2 is hydroxy, C1-4 alkoxy N,N-di (C1-4 alkyl)-amino-(C1-4 alkoxy), C1-4 hydroxyalkoxy, carboxy-(C1-4 alkoxy), amino, C1-4 alkylamino, di(C1-4alkyl)amino, C1-4 alkylsulfonylamino, carboxy(C1-4 alkyl)amino, carbamoyl-(C1-4 alkyl)amino or 2-imino-3-methylthiazolidine with the proviso that R2 is not hydroxy when n is O und R is hydrogen; and the pharmaceutically acceptable salts thereof. These compounds can be used in the treatment and control of allergic conditions such as allergic asthma and pharmaceutical compositions containing the compounds and methods of making the compounds are also provided.
IPC 1-7
IPC 8 full level
C07D 337/14 (2006.01); C07D 409/04 (2006.01); C07D 409/06 (2006.01); C07D 417/06 (2006.01)
CPC (source: EP)
C07C 323/00 (2013.01); C07D 337/14 (2013.01)
Citation (search report)
- [P] NL 7713373 A 19780606 - NIPPON CHEMIPHAR CO
- NL 7411917 A 19750317 - SANDOZ AG
Designated contracting state (EPC)
BE CH DE FR GB LU NL SE
DOCDB simple family (publication)
EP 0000978 A1 19790307; EP 0000978 B1 19820915; DE 2862028 D1 19821104; DK 330678 A 19790127; IT 7850376 A0 19780719; JP S5444692 A 19790409
DOCDB simple family (application)
EP 78300184 A 19780721; DE 2862028 T 19780721; DK 330678 A 19780725; IT 5037678 A 19780719; JP 9055078 A 19780726