EP 0002604 A1 19790627 - Quaternary ammonium salts, and their formulations and preparation.
Title (en)
Quaternary ammonium salts, and their formulations and preparation.
Title (de)
Quaternäre Ammoniumsalze, ihre Formulierungen und Herstellung.
Title (fr)
Sels d'ammonium quaternaire, leurs formulations et préparation.
Publication
Application
Priority
US 86178977 A 19771219
Abstract (en)
Novel quaternary ammonium salts of certain phenylpropylamines and phenylbutylamines are disclosed. They are useful drugs for treating arrhythmia and prolonging the action potential of cardiac muscle. They are prepared by reacting a tertiary amine with an alkyl salt.
IPC 1-7
IPC 8 full level
A61K 31/135 (2006.01); A61K 31/14 (2006.01); A61K 31/395 (2006.01); A61P 9/06 (2006.01); C07C 67/00 (2006.01); C07C 209/00 (2006.01); C07C 211/27 (2006.01); C07C 211/62 (2006.01); C07C 211/63 (2006.01); C07C 213/00 (2006.01); C07C 215/66 (2006.01); C07C 217/62 (2006.01); C07D 295/037 (2006.01); C07D 295/02 (2006.01)
CPC (source: EP)
A61K 31/135 (2013.01); A61P 9/06 (2017.12); C07C 217/62 (2013.01); C07D 295/037 (2013.01)
Citation (search report)
CHEMICAL ABSTRACTS, vol. 80, 1974, ref. 104494g Columbus, Ohio, USA R.B. HARLOW et al., "Comparison of phenylalkyl- and phenoxyalkyl- trimethylammonium and triethylammonium salts. Their apparent molal volumes at infinite dilution and effects on the frog rectus and guinea-pig ileum preparations" & Brit. J. Pharmacol. 1973, 49 (3), 480-9.
Designated contracting state (EPC)
DE GB IT NL SE
DOCDB simple family (publication)
EP 0002604 A1 19790627; EP 0002604 B1 19830504; AR 222813 A1 19810630; AT 363065 B 19810710; AT A904378 A 19801215; AU 4255478 A 19790628; AU 524727 B2 19820930; BE 872832 A 19790618; CA 1093072 A 19810106; CH 640506 A5 19840113; CS 857778 A2 19850716; DD 139842 A5 19800123; DE 2862243 D1 19830609; DK 150475 B 19870309; DK 150475 C 19871026; DK 567778 A 19790731; EG 14601 A 19840930; ES 476152 A1 19800516; FI 65425 B 19840131; FI 65425 C 19840510; FI 783845 A 19790620; FR 2411824 A1 19790713; FR 2411824 B1 19850329; GB 2011388 A 19790711; GB 2011388 B 19820428; HU 178220 B 19820328; IE 47693 B1 19840530; IE 782489 L 19790619; IL 56212 A0 19790312; IL 56212 A 19820831; JP S5495520 A 19790728; JP S6214538 B2 19870402; LU 80670 A1 19790413; NZ 189162 A 19801024; PH 14394 A 19810625; PT 68907 A 19790101; RO 76881 A2 19810830; SU 745360 A3 19800630; YU 297578 A 19821031; ZA 787111 B 19800827
DOCDB simple family (application)
EP 78300800 A 19781213; AR 27485678 A 19781220; AT 904378 A 19781218; AU 4255478 A 19781214; BE 1009197 A 19781218; CA 317877 A 19781213; CH 1284278 A 19781218; CS 857778 A 19781219; DD 20992078 A 19781219; DE 2862243 T 19781213; DK 567778 A 19781218; EG 70878 A 19781217; ES 476152 A 19781219; FI 783845 A 19781214; FR 7835393 A 19781215; GB 7848212 A 19781213; HU EI000828 A 19781218; IE 248978 A 19781218; IL 5621278 A 19781214; JP 15814878 A 19781219; LU 80670 A 19781218; NZ 18916278 A 19781213; PH 21939 A 19781213; PT 6890778 A 19781213; RO 9596778 A 19781218; SU 2705793 A 19781219; YU 297578 A 19781218; ZA 787111 A 19781219