EP 0037082 A1 19811007 - Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals.
Title (en)
Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals.
Title (de)
Verfahren zur Herstellung von 1-Carbapenem-Derivaten und von Zwischenprodukten via silyl-substituierter Dithioacetale.
Title (fr)
Procédé de préparation de composés du type 1-carbapénème et produits intermédiaires via dithioacétals substitués par des groupes silyle.
Publication
Application
Priority
US 13439780 A 19800327
Abstract (en)
Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from L-aspartic acid via central intermediates II and III: <CHEM> where R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group; R<6>, R<7> and R<8> are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; R<1> min and R<e> are hydrogen, or a readily removable protecting group; R<a>, R<b> and R<c> are selected from alkyl, aryl or aralkyl.
IPC 1-7
IPC 8 full level
C07D 205/08 (2006.01); C07D 477/00 (2006.01); C07D 477/04 (2006.01); C07D 477/10 (2006.01); C07F 7/08 (2006.01); C07F 7/10 (2006.01)
CPC (source: EP)
C07D 205/08 (2013.01); C07D 477/04 (2013.01); C07D 477/10 (2013.01); C07F 7/0812 (2013.01); C07F 7/10 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
EP 0007973 A1 19800220 - MERCK & CO INC [US]
Designated contracting state (EPC)
CH DE FR GB NL
DOCDB simple family (publication)
EP 0037082 A1 19811007; EP 0037082 B1 19850320; DE 3169321 D1 19850425; HK 30786 A 19860509; JP S5716891 A 19820128
DOCDB simple family (application)
EP 81102270 A 19810326; DE 3169321 T 19810326; HK 30786 A 19860501; JP 4534981 A 19810327