Global Patent Index - EP 0054816 A1

EP 0054816 A1 19820630 - Process for preparing N-pyrrolyl-pyridazineamine derivatives.

Title (en)

Process for preparing N-pyrrolyl-pyridazineamine derivatives.

Title (de)

Verfahren zur Herstellung von N-Pyrrolyl-Pyridazinaminderivaten.

Title (fr)

Procédé de préparation de dérivés de N-pyrrolyle-pyridazineamine.

Publication

EP 0054816 A1 19820630 (EN)

Application

EP 81110203 A 19811206

Priority

IT 2684680 A 19801222

Abstract (en)

[origin: ES8300751A1] The present invention refers to a new process for preparing N-2,3,4,5-substituted-1H-pyrrol-1-yl)-6-substituted amino-3-pyridazineamine, known as antihypertensive agents. The process is characterized in that a suitable 3,6-dihalogenopyridazine is reacted with hydrazine hydrate or other hydrazine derivatives of formula NH2 NHR, the obtained compound is reacted with a suitable dicarbonyl compound yielding first an alcandione-bis-[6-halogen-3-pyridazininyl]hydrazone, and then a 6-halogen-3-pyrrolylpyridazineamine derivative which is in turn reacted with an amine to yield the desired compounds.

IPC 1-7

C07D 403/12

IPC 8 full level

C07D 403/12 (2006.01); C07B 61/00 (2006.01); C07D 237/20 (2006.01); C07D 401/00 (2006.01)

CPC (source: EP KR US)

C07D 237/20 (2013.01 - EP US); C07D 401/00 (2013.01 - KR)

Citation (search report)

Designated contracting state (EPC)

AT BE CH DE FR GB IT LU NL SE

DOCDB simple family (publication)

EP 0054816 A1 19820630; EP 0054816 B1 19850807; AT E14729 T1 19850815; CA 1173442 A 19840828; DE 3171737 D1 19850912; DK 566181 A 19820623; ES 508175 A0 19821101; ES 8300751 A1 19821101; GR 74708 B 19840706; IE 52085 B1 19870610; IE 813005 L 19820622; IT 1150070 B 19861210; IT 8026846 A0 19801222; JP H0328432 B2 19910419; JP S57128686 A 19820810; KR 830007634 A 19831104; KR 870001625 B1 19870917; PT 74178 A 19820101; PT 74178 B 19830518; US 4385179 A 19830524

DOCDB simple family (application)

EP 81110203 A 19811206; AT 81110203 T 19811206; CA 392819 A 19811221; DE 3171737 T 19811206; DK 566181 A 19811221; ES 508175 A 19811221; GR 810166737 A 19811208; IE 300581 A 19811221; IT 2684680 A 19801222; JP 20627281 A 19811222; KR 810005072 A 19811222; PT 7417881 A 19811221; US 33227281 A 19811218