EP 0059637 A1 19820908 - 11Alpha-amino-3 Beta-hydroxy-androstanes.
Title (en)
11Alpha-amino-3 Beta-hydroxy-androstanes.
Title (de)
11alpha Amino-3beta-hydroxy-androstane.
Title (fr)
11Alpha-amino-3bêta-hydroxy androstanes.
Publication
Application
Priority
GB 8106486 A 19810302
Abstract (en)
[origin: US4451405A] Compounds of the formula <IMAGE> (I) wherein R1 is a C1-8 alkyl group or a C3-7 cycloalkyl group, and R2 is a C1-6 alkyl group or a C3-6 cycloalkyl group and the D-homo analogues thereof having the group -CO2R2 (wherein R2 is as defined above) at the 17 alpha beta -position, and acid addition salts thereof have activity as antidysthythmic agents and may be applicable for the treatment of dysrthymias in humans or animals. The compounds may be provided in the form of compositions in admixture with pharmaceutical carriers and excipients and may be prepared by a variety of processes known for producing steroids of this type. The invention also provides intermediates for the preparation of the compounds of formula (I) wherein R2 and/or R1 are replaced with hydrogen atoms, and processes for the preparation of such intermediates.
IPC 1-7
IPC 8 full level
A61K 31/56 (2006.01); A61P 9/06 (2006.01); A61P 9/10 (2006.01); C07J 41/00 (2006.01); C07J 63/00 (2006.01)
CPC (source: EP US)
A61P 9/06 (2017.12 - EP); A61P 9/10 (2017.12 - EP); C07J 41/0005 (2013.01 - EP US); C07J 41/0011 (2013.01 - EP US); C07J 63/008 (2013.01 - EP US)
Citation (search report)
- BE 853227 A 19771004 - GLAXO LAB LTD
- BE 889639 A 19820115 - GLAXO GROUP LTD
- FR 2347382 A1 19771104 - GLAXO LAB LTD [GB]
- GB 2080308 A 19820203 - GLAXO GROUP LTD
- EP 0044227 A1 19820120 - GLAXO GROUP LTD [GB]
- NL 8103358 A 19820216 - GLAXO GROUP LTD
- FR 2487359 A1 19820129 - GLAXO GROUP LTD [GB]
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0059637 A1 19820908; AU 8095782 A 19820909; GB 2093846 A 19820908; JP S57158800 A 19820930; NZ 199859 A 19841019; US 4451405 A 19840529; ZA 821337 B 19830223
DOCDB simple family (application)
EP 82301033 A 19820301; AU 8095782 A 19820301; GB 8205939 A 19820301; JP 3067482 A 19820301; NZ 19985982 A 19820301; US 44719082 A 19821206; ZA 821337 A 19820301