EP 0063509 A1 19821027 - 2-Piperazino-pyrimidine derivatives, processes for their preparation, medicaments containing them and their use as intermediates in the manufacture of medicaments.
Title (en)
2-Piperazino-pyrimidine derivatives, processes for their preparation, medicaments containing them and their use as intermediates in the manufacture of medicaments.
Title (de)
2-Piperazino-pyrimidin-Derivate, Verfahren zu ihrer Herstellung, diese enthaltende Arzneimittel und ihre Verwendung als Zwischenprodukte zur Herstellung von Arzneimitteln.
Title (fr)
Nouveaux dérivés de pipérazino-2 pyrimidine, procédés pour leur préparation, médicaments les contenant et leur utilisation comme intermédiaires pour la fabrication de médicaments.
Publication
Application
Priority
FR 8106924 A 19810407
Abstract (en)
[origin: ES8306745A1] Compounds are disclosed as useful as drugs or as intermediates for the manufacture of drugs, the compounds having the formula: < IMAGE > (I) in which X is hydrogen, chlorine, alkyl, alkoxy or alkylthio having 1 to 3 carbon atoms, R2 is hydrogen or alkyl having 1 to 3 carbon atoms, Y2 is chlorine and Y1 is chlorine or < IMAGE > in which R1 is hydrogen, straight or branched chain alkyl having 1 to 7 carbon atoms, cycloalkyl having 3 to 7 carbon atoms or cycloalkylalkyl having 4 to 8 carbon atoms, or Y2 and Y1 are both OH. Also disclosed are methods for preparation of the compounds.
Abstract (fr)
Composés, utiles comme médicaments ou comme intermédiaires pour la fabrication de médicaments, de formule: <IMAGE> dans laquelle X est un atome d'hydrogène ou de chlore ou un groupe alkyle, alcoxy ou alkylthio ayant 1 à 3 atomes de carbone, R2 est un atome d'hydrogène ou un groupe alkyle ayant 1 à 3 atomes de carbone, Y2 est un atome de chlore et Y1 est un atome de chlore ou un groupe <IMAGE> dans lequel R1 est un atome d'hydrogène, un groupe alkyle à chaîne droite ou ramifiée ayant 1 à 7 atomes de carbone, un groupe cycloalkyle ayant 3 à 7 atomes de carbone ou un groupe cycloalkylealkyle ayant 4 à 8 atomes de carbone, ou bien Y2 et Y1 sont tous les deux des groupes OH.
IPC 1-7
C07D 239/48; C07D 239/42; C07D 239/47; C07D 239/52; C07D 239/54; C07D 239/60; A61K 31/505
IPC 8 full level
A61K 31/495 (2006.01); A61P 9/12 (2006.01); A61P 25/00 (2006.01); A61P 25/24 (2006.01); A61P 25/26 (2006.01); A61P 39/02 (2006.01); C07D 239/42 (2006.01); C07D 239/46 (2006.01); C07D 239/48 (2006.01); C07D 239/52 (2006.01); C07D 239/545 (2006.01); C07D 239/60 (2006.01); C07D 239/54 (2006.01)
CPC (source: EP US)
A61P 9/12 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/26 (2017.12 - EP); A61P 39/02 (2017.12 - EP); C07D 239/42 (2013.01 - EP US); C07D 239/47 (2013.01 - EP US); C07D 239/48 (2013.01 - EP US); C07D 239/52 (2013.01 - EP US); C07D 239/545 (2013.01 - EP US); C07D 239/60 (2013.01 - EP US)
Citation (search report)
- [X] FR 2311776 A1 19761217 - SOGERAS [FR]
- [A] US 2543972 A 19510306 - EVERETT HULTQUIST MARTIN, et al
- [A] DE 1620419 B
- [AD] FR 2173746 A1 19731012 - UGINE KUHLMANN [FR]
- [AD] FR 2257294 A1 19750808 - UGINE KUHLMANN [FR]
- [AD] FR 2281117 A2 19760305 - UGINE KUHLMANN [FR]
Designated contracting state (EPC)
BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0063509 A1 19821027; EP 0063509 B1 19850220; AR 231442 A1 19841130; AT 386199 B 19880711; AT A127682 A 19871215; AU 549748 B2 19860213; AU 8245082 A 19821014; CA 1175427 A 19841002; DE 3262374 D1 19850328; DK 154382 A 19821008; DK 156722 B 19890925; DK 156722 C 19900219; ES 511224 A0 19830601; ES 518974 A0 19831016; ES 518975 A0 19831016; ES 518976 A0 19831016; ES 8306745 A1 19830601; ES 8400427 A1 19831016; ES 8400428 A1 19831016; ES 8400429 A1 19831016; FI 78909 B 19890630; FI 78909 C 19891010; FI 821203 A0 19820406; FI 821203 L 19821008; FR 2503162 A1 19821008; FR 2503162 B1 19831125; GR 77331 B 19840911; HU 187673 B 19860228; IE 52872 B1 19880330; IE 820774 L 19821007; IL 65422 A0 19820730; IL 65422 A 19850430; JP S57179167 A 19821104; MA 19438 A1 19821231; MX 156087 A 19880704; NO 158739 B 19880718; NO 158739 C 19881026; NO 821159 L 19821008; PT 74712 A 19820501; PT 74712 B 19831025; US 4535080 A 19850813; ZA 822344 B 19830223
DOCDB simple family (application)
EP 82400551 A 19820326; AR 28901282 A 19820405; AT 127682 A 19820331; AU 8245082 A 19820407; CA 400630 A 19820407; DE 3262374 T 19820326; DK 154382 A 19820405; ES 511224 A 19820406; ES 518974 A 19830113; ES 518975 A 19830113; ES 518976 A 19830113; FI 821203 A 19820406; FR 8106924 A 19810407; GR 820167575 A 19820311; HU 106782 A 19820407; IE 77482 A 19820401; IL 6542282 A 19820405; JP 5717982 A 19820406; MA 19642 A 19820405; MX 19209782 A 19820401; NO 821159 A 19820406; PT 7471282 A 19820406; US 52579983 A 19830824; ZA 822344 A 19820405