EP 0079221 A2 19830518 - Immune complex removal and tumor specific antibody generation by immobilized protein a perfusion and postperfusion drug infusion.
Title (en)
Immune complex removal and tumor specific antibody generation by immobilized protein a perfusion and postperfusion drug infusion.
Title (de)
Immune komplexe Beseitigung und Herstellung eines tumorspezifischen Antikörpers durch Perfusion mit immobilisiertem Protein A und Infusion eines Arzneimittels nach Perfusion.
Title (fr)
Elimination de complexe immun et production d'anticorps spécifique de tumeur par perfusion de protéine A immobilisée et injection de medicament après perfusion.
Publication
Application
Priority
US 32332681 A 19811106
Abstract (en)
Significantly increased removal of immunal complexes and tumor specific antibody generation are achieved by extracorporeal plasma perfusion over a therapeutic immobilized protein A (staphylococcal), SPA. The perfused plasma is returned to the host or can be taken off one person and used to treat another and stored in perfused plasma banks. Immobilized protein A quantities, volumes of plasma perfused and the rate of administration based on clinical and toxicity evaluations are set forth. A non-toxic drug infusion, such as cytosine arabinoside, during the immediate postperfusion period obtains an observed tumoricidal response far exceeding those due to the extracorporeal plasma perfusion or drug infusion alone representing an in vivo synergism between tumor specific antibody and the drug. Also disclosed are the therapeutic protein A cartridge, its loading and delivery system, a miniaturized immunoabsorbent apparatus enabling the processing of serum samples for testing small quanitities of plasma, and a radioimmuno-assay for detecting and measuring tumor specific antibodies in the serum samples for profiling and screening of patients for treatment and assessment. The United States government has rights in these inventions pursuant to U.S. Public Health Service Grants or Awards 5K04AI00302 and 5R01GM23517.
IPC 1-7
A61K 39/385; A61K 39/395; C12N 11/12; C12N 11/04; G01N 33/54; A61M 1/03
IPC 8 full level
A61K 31/70 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61M 1/34 (2006.01); A61M 1/36 (2006.01)
CPC (source: EP KR US)
A61K 39/39 (2013.01 - KR); A61M 1/3472 (2013.01 - EP US); A61M 1/3486 (2014.02 - EP US)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI NL SE
DOCDB simple family (publication)
EP 0079221 A2 19830518; EP 0079221 A3 19860122; AU 570911 B2 19880331; AU 8918982 A 19850207; CA 1197460 A 19851203; DK 487382 A 19830507; ES 517174 A0 19831201; ES 523790 A0 19841216; ES 523791 A0 19841216; ES 8402506 A1 19831201; ES 8501984 A1 19841216; ES 8503202 A1 19841216; FI 823761 A0 19821103; FI 823761 L 19830507; IL 66959 A0 19830223; JP S5886168 A 19830523; KR 840002244 A 19840625; NO 823672 L 19830509
DOCDB simple family (application)
EP 82305913 A 19821105; AU 8918982 A 19821007; CA 415005 A 19821105; DK 487382 A 19821103; ES 517174 A 19821105; ES 523790 A 19830701; ES 523791 A 19830701; FI 823761 A 19821103; IL 6695982 A 19821011; JP 19519682 A 19821106; KR 820005015 A 19821106; NO 823672 A 19821104