EP 0083612 A1 19830720 - NEW DERIVATIVES OF DIPEPTIDES, METHOD FOR THE PREPARATION THEREOF AND UTILIZATION THEREOF AS DRUGS.
Title (en)
NEW DERIVATIVES OF DIPEPTIDES, METHOD FOR THE PREPARATION THEREOF AND UTILIZATION THEREOF AS DRUGS.
Title (de)
DIPEPTIDDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE ANWENDUNG ALS ARZNEIMITTEL.
Title (fr)
NOUVEAUX DERIVES DE DIPEPTIDES, LEUR PROCEDE DE PREPARATION ET LEUR EMPLOI COMME MEDICAMENT.
Publication
Application
Priority
CH 451481 A 19810709
Abstract (en)
[origin: EP0069674A1] Dipeptide derivatives represented by the general formula Ac - A - X - Y, wherein Ac represents the acyl rest of an organic carboxylic acid. A is an amino acid carrying a carboxylic function at alpha . X is an amino acid rest and Y is hydrogen or the rest of a mono- or disubstituted amine. They are prepared by acetylation of the amino acid A and then by dihydration of the N-acetyl amino acid into anhydride, coupling with an X amino acid, new dihydration of the dipeptide N-acetyl A-X into anhydride-amide and condensation with a Y amine to form the dipeptide Ac - A - X - Y.
Abstract (fr)
Dérivés de dipeptides répondant à la formule générale Ac - A - X - Y dans laquelle Ac représente le reste acyle d'un acide organique carboxylique. A est un amino acide porteur d'une fonction carboxylique en alpha. X est un reste d'amino acide et Y est l'hydrogène ou le reste d'une amine mono- ou di-substituée. On les prépare par acetylation de l'amino acide A puis deshydratation du N-acetyl amino acide en anhydride, couplage avec un amino acide X, nouvelle deshydratation du dipeptide N-acetyl A-X en anhydride-imide puis condensation avec une amine Y pour former le dipeptide Ac - A - X - Y.
IPC 1-7
IPC 8 full level
A61K 31/185 (2006.01); A61K 31/195 (2006.01); A61P 9/12 (2006.01); C07C 309/15 (2006.01); C07K 5/072 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 9/12 (2017.12); C07C 309/15 (2013.01); C07K 5/06113 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
CH DE FR GB LI NL SE
DOCDB simple family (publication)
EP 0069674 A1 19830112; EP 0069674 B1 19850417; AT E12768 T1 19850515; CA 1190243 A 19850709; CH 665645 A5 19880531; DE 3263121 D1 19850523; EP 0083612 A1 19830720; ES 513829 A0 19830501; ES 8306106 A1 19830501; GR 78088 B 19840926; JP S5865214 A 19830418; WO 8300146 A1 19830120
DOCDB simple family (application)
EP 82401280 A 19820707; AT 82401280 T 19820707; CA 406986 A 19820709; CH 451481 A 19810709; DE 3263121 T 19820707; EP 82902071 A 19820708; ES 513829 A 19820708; FR 8200116 W 19820708; GR 820168622 A 19820701; JP 11967782 A 19820709