EP 0093851 A3 19850410 - FATTY ACID CARRIERS FOR SYNTHETIC VACCINES
Title (en)
FATTY ACID CARRIERS FOR SYNTHETIC VACCINES
Publication
Application
Priority
US 35815082 A 19820315
Abstract (en)
[origin: EP0093851A2] (A)Synthetic vaccine comprises a peptide residue coupled to an alkyl or alkenyl gp.(s) having at least 12C or other lipophilic substance. The residue contains a sequence of 6 amino acids corresp. to the sequence of such amino acids in a protein antigen or allergen where the greatest local average hydrophilicity is found. The hydrophilicity is determined by assignment of defined relative values to the amino acids of the protein. The repetitive local average of hydrophilicity values at a no. of points along the aminoacid chain are determined and the points of greatest local average hydrophilicity are determined. The vaccine when free from an amino acid sequence corresp. to the entire protein antigen or allergen evokes a protective immunological response by stimulation of antibody formation against antigen or allergen when introduced into a host animal. (B)Compsn.comprising a synthetic antigen or allergen of formula P'-NH-(CO)m-R (I) is new (P' is a peptide residue without the terminal amino gp and is as defined above; m is 0 or 1; and R is opt.substd.alkyl or alkenyl having up to 12C). (C)Compsn. comprising a synthetic antigen or allergen of formula P'-NH-(X)n-((R3)o,(R4)p,(R5)q,(R6)r) (II) is new. R3-R6 are 12-36C alkyl or alkenyl opt.substd.; o,p,q and r are 0 or 1, and their total equals n; n is 2-4; x is a polyfunctional gp.having 3-5 functional gps., at least one being bound to the terminal amino and at least one being bound to one of R3-R6). Synthetic vaccines of known and unknown protein antigens or allergens can be formed, since the important aspect is the portion of the protein providing the H-epitope. The vaccine may contain a no. of H-epitopes of single or multiple protein antigens or allergens. The entire sequence of a protein does not have to be known. The vaccines may be used to give protection against many viral diseases and bacterial diseases, or for desensitising a subject against allergens.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); A61K 38/00 (2006.01); A61K 39/29 (2006.01); A61K 39/35 (2006.01); A61K 39/385 (2006.01); C07K 14/00 (2006.01); C07K 14/02 (2006.01)
CPC (source: EP)
A61K 39/385 (2013.01); C07K 14/00 (2013.01); C07K 14/005 (2013.01); A61K 2039/6018 (2013.01); C12N 2730/10122 (2013.01)
Citation (search report)
- [X] FR 2349569 A1 19771125 - BONNIERFOERETAGEN AB [SE]
- [X] EP 0044710 A1 19820127 - SCRIPPS CLINIC RES [US]
- [XP] EP 0056249 A2 19820721 - NEW YORK BLOOD CENTER INC [US]
- [AP] WO 8204250 A1 19821209 - UNIV NORTHWESTERN [US]
- [X] PROC. NATL. ACAD. SCI. USA, vol. 79, no. 2, January 1982, pages 579-582, Immunology; A.M. PRINCE et al.: "Hepatitis B virus vaccine: Identification of HBsAg/a and HBsAg/d but not HBsAg/y subtype antigenic determinants on a synthetic immunogenic peptide"
- [XP] PROC. NATL. ACAD. SCI. USA, vol. 79, no. 14, July 1982, pages 4400-4404, Immunology; P.K. BHATNAGAR et al.: "Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant"
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI NL SE
DOCDB simple family (publication)
EP 0093851 A2 19831116; EP 0093851 A3 19850410; CA 1231094 A 19880105; JP H07116055 B2 19951213; JP S58222031 A 19831223; ZA 831547 B 19841031
DOCDB simple family (application)
EP 83102392 A 19830311; CA 423670 A 19830315; JP 4161983 A 19830315; ZA 831547 A 19830307