Global Patent Index - EP 0094821 B1

EP 0094821 B1 19900808 - PROCESS FOR THE NUCLEOPHILIC SUBSTITUTION OF UNACTIVATED AROMATIC AND HETEROAROMATIC SUBSTRATES

Title (en)

PROCESS FOR THE NUCLEOPHILIC SUBSTITUTION OF UNACTIVATED AROMATIC AND HETEROAROMATIC SUBSTRATES

Publication

EP 0094821 B1 19900808 (EN)

Application

EP 83302750 A 19830516

Priority

  • US 37899382 A 19820517
  • US 48187483 A 19830411

Abstract (en)

[origin: EP0094821A1] A process for achieving nucleophilic substitution upon an unactivated monocyclic or polycyclic aromatic or heteroaromatic substrate bearing a suitable leaving group comprising the substitution of said leaving group by an anionic nucleophile is catalyzed with a cyclic or acyclic polydentate chelating ligand, e.g. a crown ether or a cyclic polyether. The process is applicable, inter alia, as the first step in the preparation of ortho-substituted benzenesulfonyl chloride derivatives, or ortho-benzenedithiol, from ortho-dichlorobenzene.

IPC 1-7

C07B 45/06; C07C 303/00; C07C 315/02; C07C 321/24; C07D 213/70; C07D 333/34

IPC 8 full level

C07C 323/09 (2006.01); C07B 61/00 (2006.01); C07C 317/14 (2006.01); C07C 319/14 (2006.01); C07D 213/70 (2006.01); C07D 333/34 (2006.01)

CPC (source: EP)

C07C 309/00 (2013.01); C07C 317/00 (2013.01); C07C 321/00 (2013.01); C07C 323/00 (2013.01); C07D 213/70 (2013.01); C07D 333/34 (2013.01)

Citation (examination)

  • JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 96, no. 7, 3rd April 1974, pages 2252-2253: D,J.SAM et al.: "Crown ether chemistry. Substitution reactions of potassium halide and potassium hydroxide complexes of dicyclohexyl-18-crown-6"
  • THE JOURNAL OF ORGANIC CHEMISTRY, vol. 44, no. 15, 2oth July 1979, pages 2642-2646. P. COGOLLI et al.: "Nucleophilic aromatic substitution reactions of unactivated aryl halides with thiolate ions in hexamethylphosphoramide"

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU NL SE

DOCDB simple family (publication)

EP 0094821 A1 19831123; EP 0094821 B1 19900808; AU 1456883 A 19831124; AU 567874 B2 19871210; BR 8302508 A 19840117; CA 1216290 A 19870106; DE 3381789 D1 19900913; DK 217883 A 19831118; DK 217883 D0 19830516; ES 522411 A0 19860901; ES 8609187 A1 19860901; GR 81340 B 19841211; IE 56017 B1 19910327; IE 831130 L 19831117; IL 68712 A0 19830930; IL 68712 A 19910718; NZ 204235 A 19860611; SU 1281171 A3 19861230

DOCDB simple family (application)

EP 83302750 A 19830516; AU 1456883 A 19830516; BR 8302508 A 19830513; CA 427970 A 19830512; DE 3381789 T 19830516; DK 217883 A 19830516; ES 522411 A 19830516; GR 830171365 A 19830517; IE 113083 A 19830516; IL 6871283 A 19830516; NZ 20423583 A 19830516; SU 3593067 A 19830516