EP 0106652 B1 19880127 - BETA-LACTAM COMPOUNDS AND PRODUCTION THEREOF
Title (en)
BETA-LACTAM COMPOUNDS AND PRODUCTION THEREOF
Publication
Application
Priority
- JP 13906883 A 19830728
- JP 18026882 A 19821013
- JP 19489482 A 19821106
Abstract (en)
[origin: EP0106652A1] An N-protected-3-acetyl-2-azetidinone-4-carboxylic acid ester has the formula: <CHEM> wherein R1 and R2 are protecting groups. <??>The compounds are prepared by reacting a Schiff base R2-N=CH-COOR1 with diketene in the presence of an imidazole. <??>In a further step the acetyl group is reduced and the carboxyl protecting group is then removed; the resultant beta -lactam compounds are useful as intermediates for the production of carbapenem or penem derivatives.
IPC 1-7
IPC 8 full level
C07D 205/08 (2006.01)
CPC (source: EP US)
C07D 205/08 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Citation (examination)
- TETRAHEDRON LETTERS, vol. 23, no. 39, 1982, pages 4025-4026, Pergamon Press Ltd., Oxford, GB K. HIRAI et al.: "From penicillin to penem and carbapenem. C1-unit introduction at C-4 position of azetidinone"
- CHEMICAL ABSTRACTS, vol. 98, no. 13, 28th March 1983, page 582, no. 107088k, Columbus, Ohio, US M. MUEHLBACHER et al.: "Efficient synthesis of ethyl 1-aryl-4-oxoazetidine-2-carboxylates"
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI NL SE
DOCDB simple family (publication)
EP 0106652 A1 19840425; EP 0106652 B1 19880127; DE 3375481 D1 19880303; ES 526759 A0 19851001; ES 8507484 A1 19851001; US 4556514 A 19851203
DOCDB simple family (application)
EP 83306146 A 19831011; DE 3375481 T 19831011; ES 526759 A 19831013; US 54164883 A 19831013