Global Patent Index - EP 0110688 A3

EP 0110688 A3 19850731 - ANGIOGENIC FACTOR PRODUCTION

Title (en)

ANGIOGENIC FACTOR PRODUCTION

Publication

EP 0110688 A3 19850731 (EN)

Application

EP 83307202 A 19831125

Priority

GB 8234066 A 19821130

Abstract (en)

[origin: EP0110688A2] @ New angiogenic factors of low molecular weight (under 1000), useful as treatment agents for wound healing and for biological assaying, made from in vitro cultures of a wide variety of tumour cells by a treatment which breaks up the proteinaceous tumour angiogenesis factors («TAF») in them and liberates the more mobile low molecular weight factors. The treatment can be applied to cell extracts or the aqueous portion of the culture, and the proteinaceous part may be rendered insoluble or captured chemically so as to release the new factor. Separation techniques which can be use include solvent extraction of dried liquid fractions, using polar solvents such as ethanol, and the liberated factor can be purified chromatographically using adsorbents for which the factor has affinity, especially a basic adsorbent and preferably polysaccharide- based, followed by elution.

IPC 1-7

C12P 1/00; A61K 35/12

IPC 8 full level

A61K 35/12 (2006.01); A61K 35/13 (2015.01)

CPC (source: EP US)

A61K 35/13 (2013.01 - EP US)

Citation (search report)

  • [X] CHEMICAL ABSTRACTS, vol. 95, no. 19, 9th November 1981, page 529, no. 166762m, Columbus, Ohio, US; A. FENSELAU et al.: "Tumor angiogenic factor. Purification from the Walker 256 rat tumor" & J. BIOL. CHEM. 1981, 256(18), 9605-11
  • [X] CHEMICAL ABSTRACTS, vol. 92, no. 9, 3rd March 1980, page 469, no. 74017g, Columbus, Ohio, US; J.B. WEISS et al.: "An angiogenic factor isolated from tumors: a potent low-molecular-weight compound" & BR. J. CANCER 1979, 40(3), 493-6
  • [XP] CHEMICAL ABSTRACTS, vol. 98, no. 25, 20th June 1983, page 132, no. 210628k, Columbus, Ohio, US; J.B. WEISS et al.: "Activation of a procollagenase by low-molecular-weight angiogenesis factor" & BIOSCI. REP. 1983, 3(2), 171-7
  • [XP] CHEMICAL ABSTRACTS, vol. 100, no. 3, 16th January 1984, page 361, no. 21108q, Columbus, Ohio, US; J.B. WEISS et al.: "Potentiating effect of heparin in the activation of procollagenase by a low-Mr angiogenesis factor" & FEBS LETT. 1983, 163(1), 62-5

Designated contracting state (EPC)

DE GB SE

DOCDB simple family (publication)

EP 0110688 A2 19840613; EP 0110688 A3 19850731; EP 0110688 B1 19900228; DE 3381236 D1 19900405; GB 2131294 A 19840620; GB 2131294 B 19870610; GB 8331476 D0 19840104; US 4698301 A 19871006

DOCDB simple family (application)

EP 83307202 A 19831125; DE 3381236 T 19831125; GB 8331476 A 19831125; US 55617483 A 19831129