EP 0119259 A1 19840926 - NON A, NON B HEPATITIS VIRUS, METHODS OF IDENTIFICATION, PURIFICATION, CHARACTERIZATION, DIAGNOSIS AND IMMUNIZATION.
Title (en)
NON A, NON B HEPATITIS VIRUS, METHODS OF IDENTIFICATION, PURIFICATION, CHARACTERIZATION, DIAGNOSIS AND IMMUNIZATION.
Title (de)
NICHT A, NICHT B, HEPATITIS-VIRUS, VERFAHREN ZUR BESTIMMUNG, REINIGUNG, KENNZEICHNUNG, DIAGNOSE UND IMMUNISIERUNG.
Title (fr)
VIRUS DE L'HEPATITE NON A, NON B, PROCEDES D'IDENTIFICATION, DE PURIFICATION, DE CARACTERISATION, DE DIAGNOSTIC ET D'IMMUNISATION.
Publication
Application
Priority
US 41870882 A 19820916
Abstract (en)
[origin: WO8401107A1] A purified form of a DNA virus which has the following characteristics: molecular weight greater than 2 X 10<6> Daltons; substantial immunoreactivity towards an anti-HBsAg monoclonal antibody 5D3; substantially no immunoreactivity towards an anti-HBsAg monoclonal antibody obtained from cell line ATCC CRL 8018; concentration dependent immunoreactivity towards polyclonal IgG anti-HBsAg antibodies, which increases with increased concentration of said DNA virus; discrete particulate form when observed by immunoelectron microscopy in the presence of IgM antibodies from cell line ATCC HB 8058; the DNA of said virus showing hybridization with DNA from hepatitis B viral DNA; and said DNA virus showing, in chimpanzees, infectivity having the characteristics of non A, non B hepatitis.
Abstract (fr)
Forme purifiée d'un virus d'ADN possédant les caractéristiques suivantes: poids moléculaire supérieur à 2 X 106 daltons; immunoréactivité substantielle envers un anticorps monoclone 5D3 anti-HBsAg; pratiquement aucune immunoréactivité envers un anticorps monoclone anti-HBsAg obtenue à partir d'une ligne cellulaire ATCC CRL 8018; immunoréactivité dépendant de la concentration envers des anticorps polyclones anti-HBsAg IgG qui augmente lorsque la compensation du virus d'ADN augmente; forme particulaire séparée lorsqu'on l'observe par microscopie immunoélectronique en présence d'anticorps IgM provenant d'une ligne cellulaire ATCC HB 8058; l'ADN dudit virus montrant des signes d'hybridation avec l'ADN provenant de l'ADN viral de l'hépatite B; et ledit virus d'ADN présentant chez les chimpanzés une infectivité possédant les caractéristiques de l'hépatite non A, non B.
IPC 1-7
IPC 8 full level
C12N 7/00 (2006.01); A61K 39/29 (2006.01); C12N 7/04 (2006.01); C12Q 1/70 (2006.01); G01N 33/576 (2006.01)
CPC (source: EP)
A61K 39/12 (2013.01); A61K 39/29 (2013.01); C07K 16/082 (2013.01); G01N 33/5767 (2013.01); C07K 2317/30 (2013.01); C12N 2770/24234 (2013.01)
Designated contracting state (EPC)
AT BE CH DE FR GB LI LU NL SE
DOCDB simple family (publication)
WO 8401107 A1 19840329; EP 0119259 A1 19840926; EP 0119259 A4 19880804; JP S59501774 A 19841025
DOCDB simple family (application)
US 8301412 W 19830916; EP 83903249 A 19830916; JP 50323683 A 19830916