EP 0121350 B1 19870513 - SUBSTITUTED UNSATURATED MERCAPTOCARBOXYLIC ACIDS AND DERIVATIVES AS LEUKOTRIENE ANTAGONISTS
Title (en)
SUBSTITUTED UNSATURATED MERCAPTOCARBOXYLIC ACIDS AND DERIVATIVES AS LEUKOTRIENE ANTAGONISTS
Publication
Application
Priority
- US 47277283 A 19830307
- US 47277383 A 19830307
- US 47277483 A 19830307
Abstract (en)
[origin: EP0121350A2] The compounds represented by the formula (I) <CHEM> wherein m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; R1 is hydrogen, amino or -NH@CH3; R2 is hydroxyl, amino, <CHEM> -NHCH2CONH2; and X is -CO2H, -CH2OH, -@ @CH2OH or -@H(CH2)nCOR, wherein n is 1 or 2, Y is hydrogen or hydroxyl or amino with the proviso that when m is 0, R1 is hyrogen, or pharmaceutically acceptable salt thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.
IPC 1-7
C07C 149/20; C07C 149/23; C07K 1/06; C07C 149/243; A61K 31/10; A61K 31/185; A61K 31/16; A61K 37/02; C07D 303/38; C07D 303/40; C07D 303/46
IPC 8 full level
A61K 31/215 (2006.01); A61K 31/70 (2006.01); C07D 303/14 (2006.01); C07D 303/40 (2006.01); C07D 307/33 (2006.01)
CPC (source: EP)
C07C 323/00 (2013.01); C07D 303/14 (2013.01); C07D 303/40 (2013.01); C07D 307/33 (2013.01)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0121350 A2 19841010; EP 0121350 A3 19850123; EP 0121350 B1 19870513; AU 2535284 A 19840913; AU 569064 B2 19880121; AU 587922 B2 19890831; AU 8212187 A 19880331; DE 3463653 D1 19870619; DK 130984 A 19840908; DK 130984 D0 19840229; ES 530310 A0 19860116; ES 8604134 A1 19860116; GR 79832 B 19841031; PT 78196 A 19840401; PT 78196 B 19860424
DOCDB simple family (application)
EP 84301433 A 19840305; AU 2535284 A 19840307; AU 8212187 A 19871204; DE 3463653 T 19840305; DK 130984 A 19840229; ES 530310 A 19840306; GR 840173986 A 19840302; PT 7819684 A 19840302