EP 0123543 B1 19880203 - LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM
Title (en)
LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM
Publication
Application
Priority
US 48733183 A 19830421
Abstract (en)
[origin: EP0123543A1] Compounds of the forrnula I: <CHEM> and their pharmaceutically acceptable salts are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders. For this purpose they are made into pharmaceutical composition. In the formula, A/ &cir& and B are hydrogen or certain rings, X is O, S, SO, or SO2; Y is H, OH, O, or OR<2>; n is 0, 1 or 2; a, b and c are 0 to 5; R<1> is one of CH2OH, CHO, tetrazolyl, CN, certain phenolic heterocycles, certain esterfied carboxyls, hydroxymethyl ketone, and certain substituted carbamoyl and sulfonylamino groups; and R<2> and R<3> are H or alkyl or form a ring.
IPC 1-7
C07C 149/32; C07C 147/06; C07C 147/14; C07C 101/447; C07D 309/10; C07D 311/24; C07D 405/12
IPC 8 full level
A61K 31/045 (2006.01); A61K 31/075 (2006.01); A61K 31/095 (2006.01); A61K 31/11 (2006.01); A61K 31/12 (2006.01); A61K 31/16 (2006.01); A61K 31/215 (2006.01); A61K 31/275 (2006.01); A61K 31/35 (2006.01); A61K 31/351 (2006.01); A61K 31/352 (2006.01); A61K 31/38 (2006.01); A61K 31/381 (2006.01); A61K 31/47 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 17/00 (2006.01); A61P 27/16 (2006.01); A61P 37/08 (2006.01); C07C 27/00 (2006.01); C07C 45/00 (2006.01); C07C 47/26 (2006.01); C07C 67/00 (2006.01); C07C 69/66 (2006.01); C07C 205/38 (2006.01); C07C 213/00 (2006.01); C07C 217/76 (2006.01); C07C 217/78 (2006.01); C07C 227/00 (2006.01); C07C 229/22 (2006.01); C07C 231/00 (2006.01); C07C 233/66 (2006.01); C07C 233/78 (2006.01); C07C 235/04 (2006.01); C07C 235/28 (2006.01); C07C 235/34 (2006.01); C07C 235/38 (2006.01); C07C 253/00 (2006.01); C07C 255/02 (2006.01); C07C 255/06 (2006.01); C07C 301/00 (2006.01); C07C 303/22 (2006.01); C07C 303/40 (2006.01); C07C 311/00 (2006.01); C07C 313/00 (2006.01); C07C 313/28 (2006.01); C07C 317/00 (2006.01); C07C 317/18 (2006.01); C07C 317/24 (2006.01); C07C 317/28 (2006.01); C07C 317/44 (2006.01); C07C 317/46 (2006.01); C07C 323/22 (2006.01); C07C 323/41 (2006.01); C07C 323/56 (2006.01); C07C 323/61 (2006.01); C07C 323/62 (2006.01); C07C 323/63 (2006.01); C07D 215/54 (2006.01); C07D 303/40 (2006.01); C07D 307/85 (2006.01); C07D 309/30 (2006.01); C07D 309/36 (2006.01); C07D 309/40 (2006.01); C07D 311/14 (2006.01); C07D 311/16 (2006.01); C07D 311/18 (2006.01); C07D 311/22 (2006.01); C07D 311/24 (2006.01); C07D 333/08 (2006.01); C07D 333/24 (2006.01); C07D 333/38 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07F 7/18 (2006.01); C07K 5/06 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 17/00 (2017.12); A61P 27/16 (2017.12); A61P 37/08 (2017.12); C07C 205/38 (2013.01); C07C 323/00 (2013.01); C07D 215/54 (2013.01); C07D 303/40 (2013.01); C07D 307/85 (2013.01); C07D 309/30 (2013.01); C07D 309/40 (2013.01); C07D 311/14 (2013.01); C07D 311/16 (2013.01); C07D 311/22 (2013.01); C07D 311/24 (2013.01); C07D 333/08 (2013.01); C07D 333/24 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07F 7/1804 (2013.01); C07K 5/0606 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
CH DE FR GB IT LI NL
DOCDB simple family (publication)
EP 0123543 A1 19841031; EP 0123543 B1 19880203; DE 3469169 D1 19880310; JP S6045541 A 19850312
DOCDB simple family (application)
EP 84302720 A 19840419; DE 3469169 T 19840419; JP 7877984 A 19840420