EP 0123832 B1 19871119 - PROCESS FOR THE OPTICAL RESOLUTION OF A MIXTURE OF THE ENANTIOMERS OF TRANS-3-((4-METHOXYPHENOXY)-METHYL)-1-METHYL-4-PHENYLPIPERIDINE
Title (en)
PROCESS FOR THE OPTICAL RESOLUTION OF A MIXTURE OF THE ENANTIOMERS OF TRANS-3-((4-METHOXYPHENOXY)-METHYL)-1-METHYL-4-PHENYLPIPERIDINE
Publication
Application
Priority
DK 111583 A 19830307
Abstract (en)
[origin: EP0123832A1] A mixture of enantiomers of trans-3-[(4-methoxyphenoxy)-methyl]-1-methyl-4-phenylpiperidine is separated into the optically active pure forms by reacting it with an enantiomer of mandelic acid or a derivative thereof to form two diastereomeric compounds and by precipitating one of the diastereomeric compounds formed. The precipitated compound is subsequently separated and is optionally converted into the free base or a pharmaceutically acceptable salt thereof. The yield obtained is substantially higher than the yield obtained by a prior art process employing a tartaric acid derivative as resolving agent.
IPC 1-7
IPC 8 full level
C07C 57/00 (2006.01); C07D 211/22 (2006.01)
CPC (source: EP US)
C07D 211/22 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0123832 A1 19841107; EP 0123832 B1 19871119; AT E30910 T1 19871215; CA 1257599 A 19890718; CA 1265522 C 19900206; DE 3467574 D1 19871223; DK 111583 A 19840908; DK 111583 D0 19830307; DK 149624 B 19860818; DK 149624 C 19870202; ES 530355 A0 19850501; ES 8504710 A1 19850501; FI 80261 B 19900131; FI 80261 C 19900510; FI 840872 A0 19840305; FI 840872 A 19840908; GR 81929 B 19841212; IE 57002 B1 19920311; IE 840496 L 19840907; JP S6069065 A 19850419; NO 164594 B 19900716; NO 164594 C 19901024; NO 840847 L 19840910; US 4571424 A 19860218
DOCDB simple family (application)
EP 84102439 A 19840307; AT 84102439 T 19840307; CA 448829 A 19840305; DE 3467574 T 19840307; DK 111583 A 19830307; ES 530355 A 19840307; FI 840872 A 19840305; GR 840174014 A 19840307; IE 49684 A 19840301; JP 4220884 A 19840307; NO 840847 A 19840306; US 58472184 A 19840229