Global Patent Index - EP 0128467 A1

EP 0128467 A1 19841219 - Polypeptides having interferon activity.

Title (en)

Polypeptides having interferon activity.

Title (de)

Polypeptide mit Interferon-Aktivität.

Title (fr)

Polypeptides avec l'activité d'interféron.

Publication

EP 0128467 A1 19841219 (EN)

Application

EP 84106214 A 19840530

Priority

US 49996483 A 19830601

Abstract (en)

Polypeptides having interferon activity with an amino acid sequence corresponding to the amino acid sequence of an interteron selected from a rIFN- alpha , a hybrid rIFN- alpha , rIFN- beta and rIFN- gamma in which at least one cysteine residue has been replaced by an amino acid residue which is incapable of forming an intermolecular disulfide bond; DNA sequences coding for these polypeptides: replicable plasmidic expression vehicles containing these DNA sequences; microorganisms transformed with these expression vehicles; and methods of preparing them.

IPC 1-7

A61K 45/00; C07C 103/52; C12N 15/00; C12P 21/00; C12R 1/19

IPC 8 full level

A61K 38/21 (2006.01); C07K 1/22 (2006.01); C07K 14/52 (2006.01); C07K 14/555 (2006.01); C07K 14/56 (2006.01); C07K 14/565 (2006.01); C07K 14/57 (2006.01); C07K 16/00 (2006.01); C12N 1/20 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01); C12R 1/19 (2006.01)

CPC (source: EP)

C07K 14/555 (2013.01); C07K 14/56 (2013.01); C12N 15/10 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • EP 0042246 A2 19811223 - JAPAN FOUND CANCER [JP], et al
  • EP 0077670 A2 19830427 - GENENTECH INC [US]
  • NATURE, vol. 294, no. 5841, December 10, 1981 (London, New York) H.M. SHEPARD et al.: "A single amino acid change in IFN-b1 abolishes its antiviral activity" pages 563-565
  • THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 257, no. 19, October 10, 1982, (Baltimore, USA) E. REHBERG et al.: "Specific Molecular Activities of Recombinant and Hybrid Leucocyte Interferons" pages 11497-11502

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU NL SE

DOCDB simple family (publication)

EP 0128467 A1 19841219; AU 2891284 A 19841206; AU 577288 B2 19880922; DK 265384 A 19841202; DK 265384 D0 19840529; IL 71951 A0 19840930; JP S60100598 A 19850604; NZ 208309 A 19880429; ZA 844082 B 19850925

DOCDB simple family (application)

EP 84106214 A 19840530; AU 2891284 A 19840531; DK 265384 A 19840529; IL 7195184 A 19840529; JP 11216084 A 19840531; NZ 20830984 A 19840529; ZA 844082 A 19840529