Global Patent Index - EP 0133673 A1

EP 0133673 A1 19850306 - Medicaments containing valepotriathydrines.

Title (en)

Medicaments containing valepotriathydrines.

Title (de)

Neue valepotriathydrinhaltige Arzneimittel.

Title (fr)

Médicaments contenant des valépotriathydrines.

Publication

EP 0133673 A1 19850306 (DE)

Application

EP 84108898 A 19840727

Priority

DE 3327811 A 19830802

Abstract (en)

[origin: EP0133673B1] 1. Claims for the contracting States : BE, CH, DE, FR, GB, IT, LI, NL Use of polyacyloxycyclopenta(c)pyran compounds of the general formula I see diagramm : EP0133673,P15,F2 in which A stands for hydrogen and B stands for hydrogen or hydroxy or A and B together form a bond, of the radicals R1 to R3 one stands for isovaleroyl, another stands for acetyl and the third stands for the acyl radical of one of the following acids : isovaleric acid, beta-methylvaleric acid, alpha-isovaleroyloxyisovaleric acid, alpha-acetoxyisovaleric acid, beta-acetoxyisovaleric acid, beta-acetoxy-beta-methylvaleric acid or beta-hydroxyisovaleric acid, and X stands for halogen, cyano, thiocyano, azido or an acyloxy radical R4 COO, in which R4 is an alkyl group, optionally substituted with hydroxy, with 1 to 20 carbon atoms or an alkenyl group with 3-20 carbon atoms or a phenyl, phenylalkyl or phenylalkenyl group with up to 3 carbon atoms in the alkylene or alkenylene chain, which may be optionally substituted in the phenyl ring with halogen, trifluoromethyl, hydroxy, lower alkyl or lower alkoxy, for the production of pharmaceutical preparations for the treatment and prophylaxis of peptic ulcers and/or for the treatment of spasmodic motility disorders in the gastrointestinal tract in larger mammals and humans. 1. Claims for the contracting State : AT Use of polyacyloxycyclopenta(c)pyran compounds of the general formula I see diagramm : EP0133673,P18,F1 in which A stands for hydrogen and B stands for hydrogen or hydroxy or A and B together form a bond, of the radicals R1 to R3 one stands for isovaleroyl, another stands for acetyl and the third stands for the acyl radical of one of the following acids : isovaleric acid, beta-methylvaleric acid, alpha-isovaleroyloxyisovaleric acid, alpha-acetoxyisovaleric acid, beta-acetoxyisovaleric acid, beta-acetoxy-beta-methylvaleric acid or beta-hydroxyisovaleric acid, and X stands for halogen, cyano, thiocyano, azido or an acyloxy radical R4 COO, in which R4 is an alkyl group, optionally substituted with hydroxy, with 1 to 20 carbon atoms or an alkenyl group with 3-20 carbon atoms or a phenyl, phenylalkyl or phenylalkenyl group with up to 3 carbon atoms in the alkylene or alkenylene chain, which may be optionally substituted in the phenyl ring with halogen, trifluoromethyl, hydroxy, lower alkyl or lower alkoxy, for the production of pharmaceutical preparations for the treatment and prophylaxis of peptic ulcers and/or for the treatment of spasmodic motility disorders in the gastrointestinal tract in larger mammals and humans.

Abstract (de)

Es werden die Verwendung von Valepotriathydrinen zur Prophylaxe und Behandlung von Erkrankungen im gastrointestinalen Trakt sowie Valepotriathydrine enthaltende Arzneimittel und neue Valepotriathydrine beschrieben.

IPC 1-7

A61K 31/35; C07D 311/94

IPC 8 full level

A61K 31/35 (2006.01); A61K 31/352 (2006.01); A61P 1/00 (2006.01); C07D 311/94 (2006.01)

CPC (source: EP US)

A61P 1/00 (2017.12 - EP); C07D 311/94 (2013.01 - EP US)

Citation (search report)

  • EP 0011718 A1 19800611 - KALI CHEMIE PHARMA GMBH [DE]
  • DE 2230626 B2 19780720
  • DE 2654709 A1 19780608 - ROBINS CO INC A H
  • DE 1191515 C
  • DE 1961433 A1 19710616 - KALI CHEMIE AG [DE]
  • DE 3026579 A1 19820211 - KALI CHEMIE PHARMA GMBH [DE]
  • PATENT ABSTRACTS OF JAPAN, unexamenined applications, Sektion C, Band 5, Nr. 89, 10. Juni 1981 THE PATENT OFFICE JAPANESE GOVERNMENT Seite 92 C 58 * JP-A 56 34 627 *
  • PATENT ABSTRACTS OF JAPAN, unexamenined applications, Sektion C, Band 5, Nr. 160, 15.Oktober 1981 THE PATENT OFFICE JAPANESE GOVERNMENT Seite 40 C 75 * JP-A 56 90 011 *
  • TETRAHEDRON LETTERS, Jahrgang 1976, Nr. 15, Oxford, New York, Paris, Frankfurt, PERGAMON PRESS J. HOLZL et al. "Zur Struktur von drei gemeinen Valtrathydrinen aus Valeriania Tiliacfolia" Seiten 1171-1174
  • COMPTES RENDUS DE L'ADADEMIE BULGARE DES SCIENCES, Band 28, Nr. 5, 1975, ACAD. BULG. SCI, Sofija S.S. POPOV et al. "Biogenetic Relationship Between Some Valepotriates" Seiten 651-653 * Gesamt, insbesondere Seite 651 *
  • TETRAHEDRON, Band 29, Nr. 15, 1973, Oxford, London, New York, Paris, PERGAMON PRESS P.W. THIES "Uber die Wirkstoffe des Baldriana-X" Seiten 3213-3226 * SAeite 3214, Formelschema Verbindingen 3,4,5,6,14; Seite 3216, fig. 4; Seite3219, fig. 11; Seite 3221, Verbindungen 10,15,16,17; Seite 3223, fig. 19-21; Seite 3224, Tabelle 4; SEITE 3225; Linke Spalte letzte Zeile - Ende der Beschreibung *
  • TETRAHEDRON, Band 24, 1968, Oxford, London, New York, Paris, PERGAMON PRESS P.W. THIES "Die Konstitution der Valepotriate" Seiten 313-347 * Seite 313; Seite 314, letzter Absatz;Seite 315, linker Teil des Formelschemas; Seite 316, Linker Teil des Formelschemas; Seite 317, Herstellung der Verbindungen 18-20,22 *

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI NL

DOCDB simple family (publication)

EP 0133673 A1 19850306; EP 0133673 B1 19870624; AT E27911 T1 19870715; DE 3327811 A1 19850221; DE 3464330 D1 19870730; DK 372884 A 19850203; DK 372884 D0 19840801; HU 201044 B 19900928; HU T36109 A 19850828; JP H0528235 B2 19930423; JP S6054382 A 19850328; US 4891384 A 19900102; US 4980487 A 19901225

DOCDB simple family (application)

EP 84108898 A 19840727; AT 84108898 T 19840727; DE 3327811 A 19830802; DE 3464330 T 19840727; DK 372884 A 19840801; HU 291284 A 19840730; JP 16164284 A 19840802; US 19181988 A 19880503; US 42324989 A 19891018