Title (en)

Gel-like ointment containing indomethacin.

Title (de)

Indomethacin enthaltende, gelartige Salbe.

Title (fr)

Onguent gélatineux contenant de l'indométhacine.

Publication

EP 0135617 A1 19850403 (DE)

Application

EP 83112623 A 19831215

Priority

CH 472683 A 19830829

Abstract (en)

[origin: US4540572A] In addition to indometacin, the gel-like ointment for the topical treatment of inflammation contains a water-soluble cellulose ether or/and a polyacrylic acid, the carboxyl groups of which are neutralized by a water-soluble amine, plus water and ethanol or isopropanol; the components are present in the ratio of amounts suitable for forming a gel. Determination of the level of indometacin in the serum of humans has shown that the absorption through the skin of the active compound from the new ointment is significantly higher than that from the most closely related products.

Abstract (de)

Die gelartige Salbe zur lokalen Behandlung von Entzündungen enthält - nebst Indomethacin - einen wasserlöslichen Celluloseäther oder/und eine Polyacrylsäure, deren Carboxygruppen durch ein wasserlösliches Amin neutralisiert sind, ferner Wasser und Äthanol oder Isopropanol; die Komponenten liegen in zur Bildung eines Gels zweckmässigem Mengenverhältnis vor. Durch Bestimmung des Serumspiegels an Indomethacin beim Menschen erweist sich die Absorption des Wirkstoffs aus der neuen Salbe durch die Haut signifikant grösser als jene des nächstverwandten Präparates.

IPC 1-7

A61K 31/405; A61K 9/06

IPC 8 full level

C07D 209/28 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/405 (2006.01); A61K 47/00 (2006.01); A61P 29/00 (2006.01)

CPC (source: EP US)

A61K 9/0014 (2013.01 - EP US); A61K 31/405 (2013.01 - EP US); A61P 29/00 (2017.12 - EP)

Citation (search report)

• DE 2827018 A1 19800110 - KOWA CO
• AT 360654 B 19810126 - TOKO YAKUHIN KOGYO KK [JP]
• EP 0055029 A2 19820630 - KOWA CO [JP]
• DE 3006024 A1 19810820 - SOLVON ARZNEI VERTRIEB LIZENZ [DE]
• DE 2103833 B1 19720105
• US 4029798 A 19770614 - YAMAMOTO HISAO, et al
• DE 2854221 A1 19791004 - LANDSTINGENS INKOPSCENTRAL
• EP 0063870 A2 19821103 - SUMITOMO CHEMICAL CO [JP]
• GB 2093693 A 19820908 - CIBA GEIGY AG

Designated contracting state (EPC)

AT BE DE FR GB IT LU NL SE

DOCDB simple family (publication)

EP 0135617 A1 19850403; EP 0135617 B1 19880601; AT E34663 T1 19880615; CH 643138 A5 19840530; DE 3376799 D1 19880707; DK 163911 B 19920421; DK 163911 C 19920914; DK 401584 A 19850301; DK 401584 D0 19840822; IL 72649 A0 19841130; IL 72649 A 19871220; JP H0237891 B2 19900828; JP S6048921 A 19850316; NO 168564 B 19911202; NO 168564 C 19920311; NO 843240 L 19850301; SE 8404182 D0 19840822; SE 8404182 L 19850301; US 4540572 A 19850910; ZA 846196 B 19850327

DOCDB simple family (application)

EP 83112623 A 19831215; AT 83112623 T 19831215; CH 472683 A 19830829; DE 3376799 T 19831215; DK 401584 A 19840822; IL 7264984 A 19840810; JP 255384 A 19840110; NO 843240 A 19840814; SE 8404182 A 19840822; US 56657883 A 19831229; ZA 846196 A 19840809