EP 0143478 A1 19850605 - Stable, aqueous, acidic solution of cis-platinum, suitable for injection.
Title (en)
Stable, aqueous, acidic solution of cis-platinum, suitable for injection.
Title (de)
Stabile, wässerige, saure, zur Einspritzung geeignete Lösung von Cis-Platinum.
Title (fr)
Solution aqueuse acide stable de cis-platinum appropriée à l'injection.
Publication
Application
Priority
NL 8303657 A 19831024
Abstract (en)
A stable, aqueous, hydrochloric acid-containing solution of cis-platinum, suitable for injection, is provided, which contains no more than 1.0, preferably no more than 0.6 mg/ml of cis-platinum and sodium chloride in an amount of 0.4-1%, has a pH of 3-5 and is substantially free of other ingredients. Also a process for preparing such a solution is provided, wherein the cis-platinum is dissolved in a solution of the sodium chloride in a part of the water, the pH of this solution is adjusted to the desired value with the aid of hydrochloric acid, and the solution is then diluted with water to the desired concentration.
IPC 1-7
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 47/02 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 9/0019 (2013.01 - EP); A61K 33/243 (2018.12 - EP US); A61K 47/02 (2013.01 - EP); A61P 35/00 (2017.12 - EP)
Citation (search report)
- GB 2021946 A 19791212 - BRISTOL MYERS CO
- GB 2074028 A 19811028 - BRISTOL MYERS CO
- [XD] CHEMICAL ABSTRACTS, vol. 91, no. 6, August 6, 1979, page 316, column 1 abstract no. 44464n, COLUMBUS, OHIO (US). A.A. HINCAL et al.: "cis-Platin stability in aqueous parenteral vehicles".
- [A] CHEMICAL ABSTRACTS, vol. 95, no. 23, December 7, 1981, page 25, column 1, abstract no. 197173z, COLUMBUS, OHIO (US). C.L. LITTERST: "Alterations in the toxicity of cis-dichlorodiammineplatinum-II and in tissue localization of platinum as a function of sodium chloride concentration in the vehicle of administration".
- [XD] CHEMICAL ABSTRACTS, vol. 91, no. 6, August 6, 1979, page 316, column 1 abstract no. 44464n, COLUMBUS, OHIO (US). A.A. HINCAL et al.: "cis-Platin stability in aqueous parenteral vehicles".
- [A] CHEMICAL ABSTRACTS, vol. 95, no. 23, December 7, 1981, page 25, column 1, abstract no. 197173z, COLUMBUS, OHIO (US). C.L. LITTERST: "Alterations in the toxicity of cis-dichlorodiammineplatinum-II and in tissue localization of platinum as a function of sodium chloride concentration in the vehicle of administration".
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0143478 A1 19850605; EP 0143478 B1 19870722; AT E28402 T1 19870815; AU 3226984 A 19850613; AU 576204 B2 19880818; DE 3464849 D1 19870827; DK 160806 B 19910422; DK 160806 C 19911007; DK 504384 A 19850425; DK 504384 D0 19841023; ES 9300011 A1 19931016; FI 78837 B 19890630; FI 78837 C 19891010; FI 843286 A0 19840820; FI 843286 A 19850425; IL 72829 A0 19841130; IL 72829 A 19860930; JP S60172923 A 19850906; NL 8303657 A 19850517; NO 165277 B 19901015; NO 165277 C 19910130; NO 844225 L 19850425
DOCDB simple family (application)
EP 84201425 A 19841004; AT 84201425 T 19841004; AU 3226984 A 19840822; DE 3464849 T 19841004; DK 504384 A 19841023; ES 537033 A 19841024; FI 843286 A 19840820; IL 7282984 A 19840831; JP 22286484 A 19841022; NL 8303657 A 19831024; NO 844225 A 19841023