EP 0173629 A1 19860305 - Antibody-metal ion complexes.
Title (en)
Antibody-metal ion complexes.
Title (de)
Antikörper-Metallionen-Komplexe.
Title (fr)
Complexes d'ions métalliques conjugés avec des anticorps.
Publication
Application
Priority
- US 64632784 A 19840831
- US 64632884 A 19840831
Abstract (en)
This invention relates to antibody-metal ion complexes having a metal ion coordinately bound to a compatible chelator covalently bound to an antibody or antibody fragment. Also described are methods for intermediates in the preparation of antibody-metal ion complexes. Therapeutic and in vitro and in vivo diagnostic methods utilizing such antibody-metal ion complexes are described.
IPC 1-7
G01N 33/534; G01N 33/577; A61K 49/02; A61K 43/00; A61K 39/395
IPC 8 full level
A61K 51/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 49/08 (2006.01); A61K 51/10 (2006.01); C07K 1/113 (2006.01); C07K 14/00 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C12P 21/00 (2006.01); C12P 21/08 (2006.01); G01N 33/532 (2006.01); G01N 33/534 (2006.01); G01N 33/536 (2006.01); G01N 33/577 (2006.01)
CPC (source: EP)
A61K 49/085 (2013.01); A61K 49/16 (2013.01); A61K 51/1093 (2013.01); G01N 33/532 (2013.01); G01N 33/534 (2013.01); G01N 33/577 (2013.01); A61K 2121/00 (2013.01); A61K 2123/00 (2013.01)
Citation (search report)
- DE 3239410 A1 19830519 - HYBRITECH INC [US], et al
- CANCER DRUG DELIVERY, vol. 1, no. 2, 1984 J. POWE et al. "Labeling Monoclonal Antibodies and F(ab')2 Fragments with (111In) Indium Using cyclic DTPA Anhydride and Their In Vivo Behavior in Mice Bearing Human Tumor Xenografts" pages 125-135 * Abstract *
- SCIENCE, vol. 220, no. 4597, May 6, 1983 D.J. HNATOWICH et al. "Radioactive Labeling of Antibody: A Simple and Efficient Method" pages 613-615 * Abstract *
- CANCER TREATMENT REPORTS, vol. 68, no. 1, January 1984 JORGE A. CARRASQUILLO et al. "Diagnosis of and Therapy for Solid Tumors With Radiolabeled Antibodies and Immune Fragments" pages 317-328 * Abstract *
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0173629 A1 19860305; EP 0173629 B1 19920610; AU 4770185 A 19860324; AU 588832 B2 19890928; CA 1260827 A 19890926; DE 3586188 D1 19920716; DE 3586188 T2 19921203; DK 195186 A 19860429; DK 195186 D0 19860429; GR 852111 B 19860102; JP H06234800 A 19940823; JP H0651720 B2 19940706; JP H0733399 B2 19950412; JP S62500119 A 19870116; WO 8601410 A1 19860313
DOCDB simple family (application)
EP 85401695 A 19850829; AU 4770185 A 19850819; CA 488912 A 19850816; DE 3586188 T 19850829; DK 195186 A 19860429; GR 850102111 A 19850830; JP 20220893 A 19930816; JP 50382085 A 19850819; US 8501556 W 19850819