EP 0186019 A2 19860702 - Medicated dressing.
Title (en)
Medicated dressing.
Title (de)
Wirkstoffpflaster.
Title (fr)
Pansement médicamenteux.
Publication
Application
Priority
DE 3447072 A 19841222
Abstract (en)
[origin: ES8702794A1] The invention relates to transdermal drug patches for the controlled release of drugs to the human skin, comprising (a) an impermeable backing or covering layer, (b) a reservoir layer adjacent to, and in close contact with said backing or covering layer, said reservoir layer comprising a polymer matrix composed of a rubber and an adhesive resin material wherein said therapeutically active agent or agents are wholly or partially soluble and which is permeable to said agent or agents, (c) an adhesive layer adjacent to, and in close contact with, said reservoir layer and permeable to said therapeutically active agent or agents, and (d) a protective layer covering and adhearing to said adhesive layer and removeable therefrom for the use of said transdermal drug patch, the improvement wherein said drug or drugs in the rubber and adhesive resin material of the reservoir layer are present together with a polymer capable of swelling in water and insoluble in the rubber and adhesive resin material of the reservoir layer, the quantity of said polymer being between 3 and 30% by weight of the rubber and adhesive resin mixture. By the incorporation of this particular water-swellable polymer material in the rubber/adhesive resin mixture together with the drug which polymer material is insoluble in the matrix, in a particular proportion calculated to the weight of the rubber and adhesive resin material in particular the drug release from the patch to the skin is increased to twice or even more is achieved.
Abstract (de)
Die Erfindung betrifft Wirkstoffpflaster zur kontrollierten Abgabe von Wirkstoffen an die Haut, bestehend aus einer Deckschicht, einem damit verbundenen, wasserunlöslichen Klebefilm aus einer Kautschuk/Kleberharzmasse, in der der beziehungsweise die Wirkstoffe löslich oder teilweise löslich ist bziehungsweise sind, und einer den Klebefilm abdeckenden, wieder ablösbaren Schutzschicht, das dadurch gekennzeichnet ist, daß der beziehungsweise die Wirkstoffe in der Kautschuk/Kleberharzmasse zusammen mit einem in Wasser quellbaren, im Klebefilm nicht löslichen Polymeren in einer Menge von 3 bis 30 Gew.-%, bezogen auf das Gemisch der Kautschuk/Kleberharzmasse zusammen mit dem in Wasser quellbaren, im Klebefilm nicht löslichen Polymeren in der bestimmten Menge vorliegt, ist insbesondere eine Erhöhung der Wirkstofffreisetzung aus dem Pflaster aus das Doppelte und mehr möglich.
IPC 1-7
IPC 8 full level
A61K 9/70 (2006.01); A61L 15/44 (2006.01); A61L 15/58 (2006.01); A61L 15/60 (2006.01)
CPC (source: EP KR US)
A61K 9/70 (2013.01 - KR); A61K 9/7053 (2013.01 - EP US); A61K 9/7076 (2013.01 - EP US); A61K 9/7084 (2013.01 - EP US); A61L 15/585 (2013.01 - EP US); A61L 15/60 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0186019 A2 19860702; EP 0186019 A3 19890104; EP 0186019 B1 19931006; AT E95430 T1 19931015; AU 5146185 A 19860717; AU 576650 B2 19880901; CA 1255592 A 19890613; CS 270207 B2 19900613; CS 964785 A2 19891013; DD 243856 A5 19870318; DE 3587616 D1 19931111; DK 170060 B1 19950515; DK 596085 A 19860623; DK 596085 D0 19851220; ES 550256 A0 19870116; ES 8702794 A1 19870116; FI 82602 B 19901231; FI 82602 C 19910410; FI 855124 A0 19851220; FI 855124 A 19860623; GR 853101 B 19860415; HU 195427 B 19880530; HU T40581 A 19870128; IE 60569 B1 19940727; IE 853282 L 19860622; JP H06104623 B2 19941221; JP S61155321 A 19860715; KR 860004638 A 19860711; KR 930002272 B1 19930327; PH 22931 A 19890124; PT 81751 A 19860102; PT 81751 B 19871111; US 4668232 A 19870526; YU 201685 A 19880831; YU 46517 B 19931116
DOCDB simple family (application)
EP 85115594 A 19851207; AT 85115594 T 19851207; AU 5146185 A 19851219; CA 498375 A 19851220; CS 964785 A 19851220; DD 28491985 A 19851220; DE 3587616 T 19851207; DK 596085 A 19851220; ES 550256 A 19851220; FI 855124 A 19851220; GR 850103101 A 19851220; HU 491885 A 19851220; IE 328285 A 19851220; JP 28585085 A 19851220; KR 850009650 A 19851220; PH 33230 A 19851220; PT 8175185 A 19851220; US 81021285 A 19851218; YU 201685 A 19851220