EP 0203177 A4 19870428 - POLYPEPTIDES AND ANTIBODIES RELATED TO DEGLYCOSYLATED VIRAL GLYCOPROTEINS.
Title (en)
POLYPEPTIDES AND ANTIBODIES RELATED TO DEGLYCOSYLATED VIRAL GLYCOPROTEINS.
Title (de)
POLYPEPTIDE UND ANTIKÖRPER GEGEN ENTGLYKOSILIERTE VIRALE GLYKOPROTEINE.
Title (fr)
POLYPEPTIDES ET ANTICORPS ASSOCIES A DES GLUCOPROTEINES VIRALES DEPOURVUES DE GLUCOSE.
Publication
Application
Priority
US 67600884 A 19841129
Abstract (en)
[origin: WO8603224A1] An N-linked, carbohydrate-free polypeptide comprising an amino acid residue sequence substantially identical to that of a viral envelope N-linked glycoprotein, its related nor-virus whose envelope protein is free of N-linked carbohydrate, and methods of producing and utilizing the polypeptide. The polypeptide is substantially free of N-linked glycosylation of the glycoprotein and induces the production of antibody-containing serum that (i) provides improved cross-reactivity among related viral strains and/or (ii) neutralizes the virus of said viral glycoprotein at a greater serum dilution than does antibody-containing serum induced by the viral envelope N-linked glycoprotein when the polypeptide and the viral envelope N-linked glycoprotein are individually utilized to induce antibody production in separate host mammals of the same strain using substantially identical immunization regimens.
IPC 1-7
IPC 8 full level
C12N 7/04 (2006.01); A61K 39/12 (2006.01); C07K 14/00 (2006.01); C07K 14/11 (2006.01); C07K 14/15 (2006.01); C07K 14/155 (2006.01); C07K 14/435 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 16/10 (2006.01); C12P 21/00 (2006.01); A61K 39/00 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
C07K 14/005 (2013.01); C07K 16/1036 (2013.01); A61K 39/00 (2013.01); C12N 2740/13022 (2013.01); C12N 2760/16022 (2013.01)
Citation (search report)
- WO 8404327 A1 19841108 - HARVARD COLLEGE [US]
- WO 8502625 A1 19850620 - CETUS CORP [US]
- EP 0151475 A2 19850814 - JAPAN FOUND CANCER [JP]
- EP 0199301 A1 19861029 - HOFFMANN LA ROCHE [CH], et al
- See also references of WO 8603224A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8603224 A1 19860605; EP 0203177 A1 19861203; EP 0203177 A4 19870428; JP S62501263 A 19870521
DOCDB simple family (application)
US 8502319 W 19851120; EP 86900378 A 19851120; JP 50020485 A 19851120