Global Patent Index - EP 0204775 A4

EP 0204775 A4 19891004 - AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE.

Title (en)

AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE.

Title (de)

AMINOSÄURE UND PEPTIDINHIBITOREN FÜR MENSCHLICHE LEUKOZYTELASTASE.

Title (fr)

INHIBITEUR AUX AMINO-ACIDES ET AUX PEPTIDES DE L'ELASTASE LEUCOCYTIQUE HUMAINE.

Publication

EP 0204775 A4 19891004 (EN)

Application

EP 86900028 A 19851213

Priority

AU PG857484 A 19841214

Abstract (en)

[origin: WO8603746A1] Potent and specific inhibitor compounds for elastase - type enzymes, especially for human leucocytic elastase (HLE), are provided by combining an amino acid or short peptide with a hydrocarbon-oxycarbonyl protecting group having at least 4 carbon atoms at the N-terminal of the amino acid or peptide, and a hydrophobic hydrocarbon chain of 8 to 16 carbon atoms at the carbonyl group of the amino acid or peptide, the protecting group and the hydrophobic group being physiologically innocuous components, but providing the required inhibition. The inhibitor compounds can be expected to be useful in the treatment of elastase - type implicated diseases such as arthritis, tumor growth and emphysema.

IPC 1-7

A61K 37/02; C07C 125/065; C07C 125/067; C07C 153/09; C07K 5/06; C07K 5/08; C07K 5/10; C07K 7/06

IPC 8 full level

C12N 9/99 (2006.01); A61K 38/00 (2006.01); C07C 67/00 (2006.01); C07C 239/00 (2006.01); C07C 271/22 (2006.01); C07K 1/113 (2006.01); C07K 5/06 (2006.01); C07K 5/08 (2006.01); C07K 5/083 (2006.01); C07K 5/10 (2006.01); C07K 5/103 (2006.01); C07K 7/06 (2006.01); C07K 14/81 (2006.01)

CPC (source: EP)

C07K 5/06026 (2013.01); C07K 5/06052 (2013.01); C07K 5/0806 (2013.01); C07K 5/0808 (2013.01); C07K 5/1008 (2013.01); A61K 38/00 (2013.01); Y02P 20/55 (2015.11)

Citation (search report)

  • [Y] US 4242329 A 19801230 - ARIELLY SALO [SE], et al
  • [Y] FR 2510990 A1 19830211 - SPOFA VEREINIGTE PHARMA WERKE [CS]
  • [Y] DE 2728593 A1 19780105 - HOFFMANN LA ROCHE
  • [Y] EP 0195212 A2 19860924 - MERRELL DOW PHARMA [US]
  • [X] CHEMICAL ABSTRACTS, vol. 86, no. 3, 17th January 1977, page 452, abstract no. 16925s, Columbus, Ohio, US; U. BEITLER et al.: "Interaction between asymmetric solutes and solvents. Diamides derived from L-valine as stationary phases in gas-liquid partition chromatography", & J. CHROMATOGR. 1976, 123(1), 149-66
  • [Y] CHEMICAL ABSTRACTS, vol. 84, no. 1, 5th January 1976, page 461, abstract no. 5386z, Columbus, Ohio, US; & JP-A-75 10 569 (TAISHO PHARMACEUTICAL CO., LTD) 22-04-1975
  • [Y] CHEMICAL ABSTRACTS, vol. 101, no. 21, 19th November 1984, page 333, abstract no. 186798y, Columbus, Ohio, US; L. ROBERT et al.: "Bifunctional inhibitors as potential agents against elastolysis", & BIOCHEM. SOC. TRANS. 1984, 12(5), 876-7
  • See references of WO 8603746A1

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 8603746 A1 19860703; AU 5208386 A 19860722; AU 583578 B2 19890504; EP 0204775 A1 19861217; EP 0204775 A4 19891004; JP S62501147 A 19870507; NZ 214543 A 19900327

DOCDB simple family (application)

AU 8500317 W 19851213; AU 5208386 A 19860722; EP 86900028 A 19851213; JP 50022586 A 19851213; NZ 21454385 A 19851213