EP 0206849 A3 19870805 - METHOD FOR THE DIAGNOSIS IN VITRO OF MALIGNANT CELLS ORIGINATING FROM THE DIGESTIVE DUCT
Title (en)
METHOD FOR THE DIAGNOSIS IN VITRO OF MALIGNANT CELLS ORIGINATING FROM THE DIGESTIVE DUCT
Publication
Application
Priority
- FR 8506707 A 19850502
- FR 8516820 A 19851113
Abstract (en)
[origin: EP0502553A2] The invention relates to biologically pure human villin, characterised in that it essentially gives only a single band, with a molecular weight of 95 kD, while subjected to polyacrylamide gel electrophoresis, and characterised in that each COOH terminus comprises the following amino acid sequence: <IMAGE> The invention also relates to a peptide fragment of human villin, characterised in that it is recognised by antibodies which recognise biologically pure human villin, and to anti-villin antibodies.
IPC 1-7
G01N 33/574; G01N 33/577; C07K 15/06; C12N 5/00; C12N 15/00; C12P 21/00; C12Q 1/68
IPC 8 full level
G01N 33/574 (2006.01); A61K 39/395 (2006.01); C07H 21/04 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01); C12N 1/21 (2006.01); C12N 5/00 (2006.01); C12N 5/10 (2006.01); C12N 15/02 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/00 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/577 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
C07K 14/4735 (2013.01); C07K 16/18 (2013.01); C07K 16/3046 (2013.01); C12Q 1/6876 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/158 (2013.01)
Citation (search report)
- CHEMICAL ABSTRACTS, vol. 98, no. 9, 28 fevrier 1983, page 244, ref.no. 67511j; Columbus, Ohio, US D. DRENCKHAHN et al.: "Evidence for the association of villin with core filaments and rootlets of the intestine epithelial micorvilli.", & CELL TISSUE RES. 1983, 228(2), 409-14; Abrégé.
- CHEMICAL ABSTRACTS, vol. 100, no. 23, 4 juin 1984, page 348, ref.no. 189079e; Columbus, Ohio, US D.A. AUSIELLO et al.: "Identification of actin-binding protein and villin in toad bladder epithelia.", & AM. J. PHYSIOL. 1984, 246(1, Pt. 2), F101-F104; Abrege.
- CHEMICAL ABSTRACTS, vol. 95, no. 13, 28 septembre 1981, page 249, ref.no. 110516s; Columbus, Ohio, US J.R. GLENNEY Jr. et al.: "Demonstration of at least two different actin-binding sites in villin, a calcium-regulated modulator of F-actin organization.", & J. BIOL. CHEM. 1981, 256(15), 8156-61; Abrege.
- PASCAL, 1984, Centre de Documentation Scientifique et Technique du CNRS, Paris, FR Ref.no. 84-X-0100064 E. COUDRIER et al.: "Expression of two structural markers of brushborder intestinal mucosa: villin and a membrane glycoprotein (140KD) in a human colon carcinoma cell line.", & J. SUBMICROSC. CYTOL. 1984, 16(1), 159-160; Abrege.
- PROC. NATL. ACAD. SCI. USA, vol. 82, no. 20, octobre 1985, pages 6788-6792 P. MATSUDAIRA et al.: "Mapping the cysteine residues and actin-binding regions of villin by using antisera to the amino and carboxyl termini of the molecule.";En entier.
- PROC. NATL. AKAD. SCI. USA, vol. 82, no. 24, decembre 1985, pages 8488-8492 S. ROBINE et al.: "Can villin be used to identify malignant and undifferentiated normal digestive epithelial cells?"; En entier.
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8606494 A2 19861106; WO 8606494 A3 19870326; AT E156136 T1 19970815; DE 3650641 D1 19970904; DE 3650641 T2 19980305; DE 3689084 D1 19931104; DE 3689084 T2 19940428; EP 0206849 A2 19861230; EP 0206849 A3 19870805; EP 0206849 B1 19930929; EP 0502553 A2 19920909; EP 0502553 A3 19940525; EP 0502553 B1 19970730; JP 2698326 B2 19980119; JP 2698337 B2 19980119; JP H07188300 A 19950725; JP H08208699 A 19960813; JP H1066574 A 19980310; JP H11123091 A 19990511
DOCDB simple family (application)
FR 8600150 W 19860430; AT 92105747 T 19860430; DE 3650641 T 19860430; DE 3689084 T 19860430; EP 86400957 A 19860430; EP 92105747 A 19860430; JP 14513797 A 19970603; JP 22558798 A 19980810; JP 29011395 A 19951108; JP 29015994 A 19941124