EP 0209275 A1 19870121 - Benz-trisubstituted 2-aminotetralins.
Title (en)
Benz-trisubstituted 2-aminotetralins.
Title (de)
Benz-trisubstituierte 2-Aminotetraline.
Title (fr)
2-Aminotétralines benz-trisubstitués.
Publication
Application
Priority
US 74903085 A 19850626
Abstract (en)
The invention relates to compounds of the formula: <CHEM> wherein R<1> and R<2> are each hydrogen, n-propyl, n-butyl or 4-hydroxyphenetyl; X is hydrogen or halo; and Y is hydrogen or halo provided that one of X and Y is halo and the other is hydrogen. Also disclosed are methods for the preparation of the compounds, pharmaceutical compositions containing them and their activity as dopaminergic receptor antagonists.
IPC 1-7
IPC 8 full level
A61K 31/135 (2006.01); A61K 31/13 (2006.01); A61P 9/00 (2006.01); A61P 9/12 (2006.01); A61P 43/00 (2006.01); C07C 67/00 (2006.01); C07C 213/00 (2006.01); C07C 215/64 (2006.01)
CPC (source: EP)
A61K 31/13 (2013.01); A61P 9/00 (2017.12); A61P 9/12 (2017.12); A61P 43/00 (2017.12); C07C 215/64 (2013.01)
Citation (applicant)
- CH 637373 A5 19830729 - SANDOZ AG [CH]
- CH 637364 A5 19830729 - SANDOZ AG [CH]
- CH 637363 A5 19830729 - SANDOZ AG [CH]
- US 4465692 A 19840814 - HORN ALAN S [NL]
- G.N. WOODRUFF, TIPS, 1982, pages 59
- WEINSTOCK, J., ORG. CHEM., vol. 26, 1968, pages 3511
- NICHOLS ET AL., J. MED. CHEM., vol. 17, 1974, pages 161
- KAISER ET AL., J. MED. PHARM. CHEM., vol. 5, 1962, pages 1243
Citation (search report)
- [Y] US 3969316 A 19760713 - RAMEY CHESTER E, et al
- [Y] JOURNAL OF MEDICINAL CHEMISTRY, vol. 22, no. 11, November 1979, pages 1323-1329, American Chemical Society, US; J.Z. GINOS et al.: "Structure-activity relationships of N-substituted dopamine and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene analogues: behavioral effects in lesioned and reserpinized mice"
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0209275 A1 19870121; EP 0209275 B1 19881019; AT E38029 T1 19881115; DE 3660959 D1 19881124; JP S624250 A 19870110
DOCDB simple family (application)
EP 86304916 A 19860625; AT 86304916 T 19860625; DE 3660959 T 19860625; JP 15134686 A 19860626