EP 0210588 A2 19870204 - Antitumor polypeptide and a method of preparing the same.
Title (en)
Antitumor polypeptide and a method of preparing the same.
Title (de)
Antitumor-Polypeptid und dessen Methode zur Herstellung.
Title (fr)
Polypeptide antitumoral et méthode de sa préparation.
Publication
Application
Priority
JP 16703785 A 19850729
Abstract (en)
This invention relates to a novel anti-tumor polypeptide prepared by suspended-culture of human acute monocytic leukemia cells THP-1 under or after contact with a differentiation inducing agent. The novel anti-tumor polypeptide do not exhibit cytotoxicity against human normal cells but give cytotoxicity to human tumor cells Hela, KB and T-24 cells which is known to be insensitive to conventional TNF, and mouse tumor cells such as sarcoma 180 and L-1210. The antitumor polypeptides may be prepared by a non-expensive serum-free medium.
IPC 1-7
IPC 8 full level
A61K 35/12 (2015.01); A61K 35/15 (2015.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61P 35/00 (2006.01); C07K 1/00 (2006.01); C07K 7/00 (2006.01); C07K 14/52 (2006.01); C07K 14/525 (2006.01); C12P 21/02 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/525 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0210588 A2 19870204; EP 0210588 A3 19890104; EP 0210588 B1 19921209; AT E83246 T1 19921215; DE 3687246 D1 19930121; DE 3687246 T2 19930624; JP H064675 B2 19940119; JP S6226226 A 19870204
DOCDB simple family (application)
EP 86110139 A 19860723; AT 86110139 T 19860723; DE 3687246 T 19860723; JP 16703785 A 19850729