EP 0213175 B1 19900725 - CYSTEINE-DEPLETED MUTEINS OF BIOLOGICALLY ACTIVE HUMAN TUMOR NECROSIS FACTOR PROTEINS
Title (en)
CYSTEINE-DEPLETED MUTEINS OF BIOLOGICALLY ACTIVE HUMAN TUMOR NECROSIS FACTOR PROTEINS
Publication
Application
Priority
US 69893985 A 19850207
Abstract (en)
[origin: WO8604606A1] Synthetic muteins of biologically active human tumor necrosis factor (hTNF) wherein at least one of the two cysteine residues is deleted or replaced by another amino acid to eliminate sites for intermolecular crosslinking. The invention also relates to synthetic structural genes having DNA sequences that have been specifically designed to encode the above-described synthetic hTNF muteins.
IPC 1-7
IPC 8 full level
C07K 14/00 (2006.01); C07K 14/52 (2006.01); C07K 14/525 (2006.01); C07K 14/555 (2006.01); C07K 14/57 (2006.01); C12N 1/20 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12N 15/19 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01); C12R 1/19 (2006.01)
CPC (source: EP US)
C07K 14/525 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (examination)
European patent application 85905169.0 (Cetus corporation ; derived from PCT/US 85/01921 plublished as WO 86/02381)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8604606 A1 19860814; AU 5518086 A 19860826; DE 3672924 D1 19900830; DK 172276 B1 19980216; DK 478786 A 19861208; DK 478786 D0 19861007; EP 0213175 A1 19870311; EP 0213175 B1 19900725; FI 864036 A0 19861006; FI 864036 A 19861006; FI 99015 B 19970613; FI 99015 C 19970925; JP S62501608 A 19870702; US 4959314 A 19900925
DOCDB simple family (application)
US 8600236 W 19860203; AU 5518086 A 19860203; DE 3672924 T 19860203; DK 478786 A 19861007; EP 86901579 A 19860203; FI 864036 A 19861006; JP 50118986 A 19860203; US 69893985 A 19850207