EP 0214092 A1 19870311 - Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone.
Title (en)
Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone.
Title (de)
Absorption von psychoaktiven 2-Aryl-pyrazoloquinolinen in Form einer festen Molekulardispersion in Polyvinylpyrrolidon.
Title (fr)
Absorption d'aryl-2 pyrazoloquinoléines psychoactives sous forme d'une dispersion moléculaire solide dans la polyvinylpyrrolidone.
Publication
Application
Priority
US 76348985 A 19850808
Abstract (en)
The absorption of orally administered substantially aqueous insoluble psychoactive 2-aryl-pyrazolo [4,3-C] quinolin-3-ones of the formula <CHEM> wherein R sec is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo or trifluoromethyl, and R min is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo, trifluoromethyl, nitro, amino, mono- or di-lower alkylamino, mono- or di-lower alkylcarbamoylamino, mono- or di-lower alkylcarbamoyloxy or cyano, or a pharmaceutically acceptable salt thereof, is enhanced by administering the same in the form of a storage stable solid molecular dispersion of polyvinylpyrrolidone.
IPC 1-7
IPC 8 full level
A61K 9/14 (2006.01); A61K 31/435 (2006.01); A61K 31/47 (2006.01); A61K 47/32 (2006.01); A61P 25/24 (2006.01); A61P 25/26 (2006.01)
CPC (source: EP)
A61K 9/146 (2013.01); A61K 31/47 (2013.01); A61P 25/24 (2017.12); A61P 25/26 (2017.12)
Citation (search report)
- US 4312870 A 19820126 - YOKOYAMA NAOKATA
- CH 574245 A5 19760415 - BOEHRINGER MANNHEIM GMBH
- DE 2634004 B2 19780810
- GB 2119784 A 19831123 - ELAN CORP LTD
- GB 2050828 A 19810114 - FREUNT IND CO LTD
- US 4459298 A 19840710 - BERNARD PATRICK S [US]
- DIE PHARMAZIE, vol. 34, no. 12, 1979, VEB Verlag Volk und Gesundheit, Berlin H. KALA et al. "Anwendung der Spruhtrocknung in der Pharmazie" pages 779-784 * Page 782-783, chapter 2.4.3, especially table on page 783 *
- DIE PHARMAZIE, vol. 36, no. 2, 1981, VEB Verlag Volk und Gesundheit, Berlin H. KALA et al. "Zur Herstellung und Charakterisierung von Spruheinbettungen" pages 106-111 * Page 106, right column ; page 107 ; page 108, end ofleft column - begin of the right column ; page 110, chapter 3 ; page 111, chapter 4.4 *
Designated contracting state (EPC)
BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0214092 A1 19870311; DK 377986 A 19870209; DK 377986 D0 19860807; JP S6263519 A 19870320
DOCDB simple family (application)
EP 86810342 A 19860801; DK 377986 A 19860807; JP 18434786 A 19860807