EP 0215662 A2 19870325 - Anti-tumor protease preparations.
Title (en)
Anti-tumor protease preparations.
Title (de)
Antitumor-Proteasepräparate.
Title (fr)
Préparations de protéase antitumorale.
Publication
Application
Priority
- JP 18412686 A 19860807
- JP 20160785 A 19850913
Abstract (en)
Method of treating a tumor in a mammal comprises administering to said mammal an effective anti-tumor amount of proteases originating from microorganisms.Method of treating a tumor in a mammal comprises administering to said mammal an effective anti-tumor amount of a protease originating from a microorganism which protease is chemically modified by one of the following procedures:a) coupling with a saccharide,b) introduction of a hydrophobic polymeric group,c) alteration of electric charge of the protein surface,d) conjugation with a low molecular weight anti-tumor agent of molecular weight less than 2,000,e) formation of dimer or oligomer by cross-linking of protease molecules,f) conjugation with a synthetic polycation,g) conjugation with a synthetic polyanion, andh) combination of the above-mentioned procedures.Microorganism protease is chemically modified by one of the following procedures:a) coupling with a saccharide,b) introduction of a hydrophobic polymeric group,c) alteration of electric charge of the protein surface,d) conjugation with a low molecular weight anti-tumor agent of molecular weight less than 2,000,e) formation of dimer or oligomer by cross-linking of protease molecules,f) conjugation with a synthetic polycation,g) conjugation with a synthetic polyanion, andh) combination of the above-mentioned procedures.
IPC 1-7
IPC 8 full level
C12N 9/52 (2006.01); C12N 9/54 (2006.01); C12N 9/96 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
C12N 9/52 (2013.01 - EP US); C12N 9/54 (2013.01 - EP US); C12N 9/96 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0215662 A2 19870325; EP 0215662 A3 19881019; US 4844897 A 19890704
DOCDB simple family (application)
EP 86307088 A 19860915; US 90624086 A 19860912